ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2007
Phosphorylation of the histone H3.3 variant in mitosis and meiosis of the urochordate Oikopleura dioica.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis.Current biology : CB · 2025Article
- Integrated omic profiling of the medicinal mushroom Inonotus obliquus under submerged conditions.BMC genomics · 2023Article
- Maternal patterns of inheritance alter transcript expression in eggs.BMC genomics · 2023Article
- The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes.International journal of molecular sciences · 2022Review
- Telomere-to-telomere assembly of the genome of an individual Oikopleura dioica from Okinawa using Nanopore-based sequencing.BMC genomics · 2021Article
- Histone H3.3 beyond cancer: Germline mutations inScience advances · 2020Article
- H3S28P Antibody Staining of OkinawanF1000Research · 2020Article
- The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.Journal of molecular biology · 2017Review
- Lifespan extension in a semelparous chordate occurs via developmental growth arrest just prior to meiotic entry.PloS one · 2014Article
- OikoBase: a genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica.Nucleic acids research · 2013Article
- Histone variant innovation in a rapidly evolving chordate lineage.BMC evolutionary biology · 2011Article
- Histone variants--ancient wrap artists of the epigenome.Nature reviews. Molecular cell biology · 2010Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian histone variant H3.3 differs from replication-dependent histone H3.1 by five amino acids, including replacement of alanine 31 by serine. H3.3 is expressed throughout the cell cycle, primarily deposited at transcriptionally active loci independent of S-phase. Data from mammalian cells suggest that phosphorylation of serine 31 (H3.3S31P) plays a role in mitosis. Here we show that H3.3S31P also occurs during mitosis of the urochordate Oikopleura dioica, suggesting this histone modification and its function in mitosis is already present at the invertebrate-vertebrate transition. The spatial pattern differed from that of H3 phosphorylation at serine 28 (H3S28P). H3S28P was enriched near telomeric regions, but H3.3S31P differed both temporally and spatially from the mammalian pattern, being more widely distributed throughout prophase, prometaphase and metaphase chromosomes. We also identified an important role for H3.3S31P during oogenic meiosis in the semelparous O. dioica. H3.3S31P initiated together with H3S28P in all meiotic nuclei in late diplotene, after H3S10P. However, H3.3S31P was retained only on the subset of meiotic nuclei that seeded maturing oocytes and proceeded through meiosis to arrest in metaphase I. Thus, this epigenetic mark is part of a regulatory circuitry that enables O. dioica to numerically adjust oocyte production over two orders of magnitude.
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