Evidence map›Paper›PMID 17333457›Full record

ArticleLasers in medical science2007

Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals.

Karin Przyklenk, Peter Whittaker

Abstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Murine hindlimb ischemia models: a narrative review.Frontiers in cardiovascular medicine · 2025
    Review
  3. Article
  4. Article
  5. Thrombus formation induced by laser in a mouse model.Experimental and therapeutic medicine · 2014
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Karin PrzyklenkDepartment of Emergency Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Karin.Przyklenk@umassmed.edu
Peter Whittaker
University of Massachusetts Chan Medical School · US

Funding

Time Domains of Sympathetic Activity following HypoxiaR01HL072648 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEISS, JAMES WOODROW · 2003 to 2006
$1.6M
NHLBI NIH HHS R01 HL072648
6 · The paper itself

Abstract

Platelet-mediated thrombosis represents the initial precipitating event in the genesis of unstable angina, acute myocardial infarction, and stroke. As a result, there is considerable interest in the preclinical discovery and screening of new 'anti-platelet' therapies aimed at limiting the incidence and reoccurrence of arterial thrombosis-efforts that, to date, have largely required the use of large animal models of thrombotic occlusion. In the current report, we describe the successful development of a small-animal (rat) model of spontaneous and recurrent platelet-mediated arterial thrombosis achieved by the in vivo administration of a photoactive dye (rose bengal) followed by focal illumination with green laser light.

Indexed as

Disease Models, AnimalLasersAnimalsFemoral ArteryPhotochemistryPlatelet AggregationRatsRecurrenceRose BengalThrombosisRose Bengal

Identifiers

PMID17333457
OpenAlexW1989504474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.