ArticleVirchows Archiv : an international journal of pathology2007
Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Extent of Resection and Long-Term Outcomes for Appendiceal Adenocarcinoma: a SEER Database Analysis of Mucinous and non-Mucinous Histologies.Annals of surgical oncology · 2024Article
- Review
- Pattern of MUC6 expression across 119 different tumor types: A tissue microarray study on 15 412 tumors.Pathology international · 2023Article
- Gross Cystic Disease Fluid Protein-15 (GCDFP-15) Expression Characterizes Breast Mucinous Carcinomas in Older Women.Diagnostics (Basel, Switzerland) · 2022Article
- Histiocytoid variant of invasive lobular breast carcinoma. A case report and literature review.Annals of medicine and surgery (2012) · 2021Article
- Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors.Cancers · 2021Review
- Histiocytoid breast carcinoma, neither lobular nor ductal? A case report and literature review.Translational cancer research · 2020Article
- Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges.Ocular oncology and pathology · 2019Article
- Mucin 2 (MUC2) modulates the aggressiveness of breast cancer.Breast cancer research and treatment · 2019Article
- Ramifications of secreted mucin MUC5AC in malignant journey: a holistic view.Carcinogenesis · 2018Review
- Histiocytoid breast carcinoma: a case report showing immunohistochemical profiles.International journal of clinical and experimental pathology · 2013Article
- Article
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7 authors at 4 institutions in 1 country.
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Abstract
The clinicopathological profiles of histiocytoid carcinoma of the breast have not been well examined because of their rarity and heterogenous groups of ductal and lobular origin. A large foamy or granular cytoplasm of histiocytoid carcinoma was characterized by abundant mucin, but the properties of mucin in histiocytoid carcinoma have also not been well investigated. We selected eight cases of histiocytoid features of invasive lobular carcinoma (HLC) and compared with 14 age- and tumor size-matched cases of classical invasive lobular carcinoma (CLC). Mucin profiles were significantly different between the two groups: a fair number of HLC cases were immunopositive for MUC2 and MUC5AC (75 and 50%, respectively); in contrast, almost all CLC cases showed both as negative. Both groups were immunopositive for MUC1 and negative for MUC4 and MUC6. The prognosis of HLC was significantly worse than CLC; HLC showed shorter disease-free time than CLC (p=0.0262). In particular, HLC with MUC2 and MUC5AC expressions showed significantly shorter disease-free time and survival time than lobular carcinoma without the expressions of MUC2 and MUC5AC (p=0.0055 and p=0.0060, respectively). Therefore, the expression of 'non-mammary mucins', such as MUC2 and MUC5AC in HLC, is characteristic and indicates the more malignant transformation of tumor cells and poorer prognosis.
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