Evidence map›Paper›PMID 17333000›Full record

ReviewPediatric nephrology (Berlin, Germany)2007

Potassium transport in the maturing kidney.

Sevgi Gurkan, Genevieve K Estilo, Yuan Wei, Lisa M Satlin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.American journal of physiology. Renal physiology · 2018
    Article
  4. Potassium regulation in the neonate.Pediatric nephrology (Berlin, Germany) · 2017
    Article
  5. NBCe1 expression is required for normal renal ammonia metabolism.American journal of physiology. Renal physiology · 2015
    Article
  6. Regulation of Potassium Homeostasis.Clinical journal of the American Society of Nephrology : CJASN · 2015
    Review
  7. Early appearance of hypokalemia in Gitelman syndrome.Pediatric nephrology (Berlin, Germany) · 2010
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sevgi GurkanDepartment of Pediatrics, Division of Nephrology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1664, New York, NY, 10029, USA.
Genevieve K Estilo
Yuan Wei
Lisa M Satlin

Funding

Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
Biomechanical Regulation of Renal Ion TransportersR37DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2006 to 2015
$3.2M
SODIUM CHANNELS IN THE MAMMALIAN URINARY BLADDERR01DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R. · 1996 to 2005
$1.5M
RENAL INTERCALATED CELL REGULATION AND DIFFERENTIATIONR29DK038470 · NIDDK · YESHIVA UNIVERSITY · PI SATLIN, LISA M. · 1986 to 1990
–
NIDDK NIH HHS DK038470NIDDK NIH HHS DK051391
6 · The paper itself

Abstract

The distal nephron and colon are the primary sites of regulation of potassium (K(+)) homeostasis, responsible for maintaining a zero balance in adults and net positive balance in growing infants and children. Distal nephron segments can either secrete or reabsorb K(+) depending on the metabolic needs of the organism. In the healthy adult kidney, K(+) secretion predominates over K(+) absorption. Baseline K(+) secretion occurs via the apical low-conductance secretory K(+) (SK) channel, whereas the maxi-K channel mediates flow-stimulated net urinary K(+) secretion. The K(+) retention characteristic of the neonatal kidney appears to be due not only to the absence of apical secretory K(+) channels in the distal nephron but also to a predominance of apical H-K-adenosine triphosphatase (ATPase), which presumably mediates K(+) absorption. Both luminal and peritubular factors regulate the balance between K(+) secretion and absorption. Perturbation in any of these factors can lead to K(+) imbalance. In turn, these factors may serve as effective targets for the treatment of both hyper-and hypokalemia. The purpose of this review is to present an overview of recent advances in our understanding of mechanisms of K(+) transport in the maturing kidney.

Indexed as

AnimalsExtracellular Signal-Regulated MAP KinasesH(+)-K(+)-Exchanging ATPaseHumansIon TransportKidneyKidney Tubules, CollectingLarge-Conductance Calcium-Activated Potassium ChannelsModels, BiologicalPotassiumPotassium Channels, Inwardly RectifyingExtracellular Signal-Regulated MAP KinasesH(+)-K(+)-Exchanging ATPaseLarge-Conductance Calcium-Activated Potassium ChannelsPotassiumPotassium Channels, Inwardly Rectifying

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.