ArticleThe Journal of clinical investigation2007
HDL proteomics: pot of gold or Pandora's box?
Article in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- High-density lipoprotein: a biomarker and therapeutic target in sepsis.Critical care (London, England) · 2025Review
- Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma.Journal of proteome research · 2018Article
- Predicting candidate genes based on combined network topological features: a case study in coronary artery disease.PloS one · 2012Article
- High-density lipoprotein (HDL) cholesterol: leveraging practice-based biobank cohorts to characterize clinical and genetic predictors of treatment outcome.The pharmacogenomics journal · 2011Review
- Corticosteroid treatment of kidney disease in a patient with familial lecithin-cholesterol acyltransferase deficiency.Clinical and experimental nephrology · 2011Article
- A practical approach to lipid management in the elderly.The journal of nutrition, health & aging · 2011Article
- High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality.Current cardiovascular risk reports · 2010Article
- Dysfunctional high-density lipoprotein.Current opinion in endocrinology, diabetes, and obesity · 2009Review
- HDL: bridging past and present with a look at the future.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Review
- Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Biomarkers related to aging in human populations.Advances in clinical chemistry · 2008Review
- Low-carbohydrate diets, obesity, and metabolic risk factors for cardiovascular disease.Current atherosclerosis reports · 2007Review
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of the JCI, Vaisar et al. studied the proteome of HDL (see the related article beginning on page 746). They reveal, quite unexpectedly, that HDL is enriched in several proteins involved in the complement cascade, as well as in a variety of protease inhibitors, supporting the concept that HDL plays a role in innate immunity and in the regulation of proteolytic cascades involved in inflammatory and coagulation processes. The protein makeup of HDL also appears to be altered in patients with coronary artery disease. HDL proteomics is in its infancy, and preliminary findings will need to be confirmed using standardized approaches in larger clinical samples. However, this approach promises to better elucidate the relationship of HDL to atherosclerosis and its complications and could eventually help in the development of biomarkers to predict the outcome of interventions that alter HDL levels and functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.