Evidence map›Paper›PMID 17332882›Full record

ReviewThe Journal of clinical investigation2007

The role of CXC chemokines in pulmonary fibrosis.

Robert M Strieter, Brigitte N Gomperts, Michael P Keane

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 272 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Immunobiology of pulmonary fibrosis.Frontiers in immunology · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Immune Mechanisms of Pulmonary Fibrosis with Bleomycin.International journal of molecular sciences · 2023
    Review
  19. Cytokine signaling converging onFrontiers in immunology · 2023
    Article
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Robert M StrieterDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. strieter@virginia.edu
Brigitte N Gomperts
Michael P Keane
Pediatric Oncology Group · CAUniversity of California, Los Angeles · USUniversity of Virginia · US

Funding

Th2 cytokines and CC chemokines in pulmonary fibrosisP50HL067665 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STRIETER, ROBERT M · 2002 to 2005
$5.5M
CXC Chemokines in CancerR01CA087879 · NCI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2000 to 2010
$3.4M
Chemokines and Fibrocytes in Acute Lung InjuryR01HL066027 · NHLBI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2001 to 2009
$3.2M
CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASER01AR055075 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTH, MICHAEL D · 2006 to 2009
$1.3M
NCI NIH HHS CA87879NCI NIH HHS R01 CA087879NHLBI NIH HHS HL03906NHLBI NIH HHS HL087849NHLBI NIH HHS HL66027NHLBI NIH HHS P50 HL067665NHLBI NIH HHS P50 HL67665NHLBI NIH HHS R01 HL066027NIAMS NIH HHS AR 055075NIAMS NIH HHS R01 AR055075
6 · The paper itself

Abstract

The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.

Indexed as

Amino Acid SequenceCell ProliferationChemokines, CXCFibroblastsHumansLungMolecular Sequence DataNeovascularization, PathologicPulmonary FibrosisStem CellsChemokines, CXC

Identifiers

PMID17332882
PMCPMC1804376
OpenAlexW2027756860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.