ArticleAmerican journal of respiratory and critical care medicine2007
Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
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- Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung Cancer.Molecules (Basel, Switzerland) · 2022Article
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- Bleomycin Induces Drug Efflux in Lungs. A Pitfall for Pharmacological Studies of Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2020Article
- Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome.Orphanet journal of rare diseases · 2019Article
- Article
- Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.JCI insight · 2017Article
- miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.Nature communications · 2015Article
- Fetal lung and placental methylation is associated with in utero nicotine exposure.Epigenetics · 2014Article
- Dysregulation of galectin-3. Implications for Hermansky-Pudlak syndrome pulmonary fibrosis.American journal of respiratory cell and molecular biology · 2014Article
- Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-β receptor I internalization and inhibiting transforming growth factor-β1 signaling.American journal of respiratory and critical care medicine · 2013Article
- Natural history of pulmonary fibrosis in two subjects with the same telomerase mutation.Chest · 2011Article
- The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis.PloS one · 2011Article
- Macrophage-derived biomarkers of idiopathic pulmonary fibrosis.Pulmonary medicine · 2011Article
- Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent.The Journal of experimental medicine · 2010Article
- Alveolar macrophage dysregulation in Hermansky-Pudlak syndrome type 1.American journal of respiratory and critical care medicine · 2009Article
- Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.PLoS medicine · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleAlveolar macrophages are inflammatory cells that may contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF), which is characterized by excessive alveolar aggregation of cells and extracellular matrix proteins.
objectivesTo identify potential molecular mechanisms of IPF.
methodsTo examine large-scale gene expression, messenger RNA isolated from alveolar macrophages and peripheral blood mononuclear cells from subjects with IPF and normal volunteers was hybridized to cDNA filters. MEASUREMENTS AND MAIN
resultsWe showed that in IPF there is global down-regulation of gene expression in alveolar macrophages but not in blood monocytes. Nuclear run-on and pulse-chase studies showed that alveolar macrophages had significantly reduced transcription (p < 0.01). No significant difference in RNA degradation was found between subjects with IPF and normal volunteers. Western blot analyses revealed that concentrations of transcription factor II-H, a general transcription factor, were significantly lower in alveolar macrophages from subjects with IPF than in those from normal volunteers (p = 0.012).
conclusionsImpaired transcription in IPF is associated with decreased concentrations of transcription factor II-H in alveolar macrophages and may alter the intraalveolar milieu in IPF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.