ArticleCancer research2007
Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
Article in Cancer research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 79 citations in OpenAlex.
- Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo.PloS one · 2025Article
- Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels.BMC cancer · 2023Article
- ING Proteins: Tumour Suppressors or Oncoproteins.Cancers · 2021Review
- mRNA and protein of p33ING1 in normal and cancer tissues.Translational cancer research · 2020Article
- Senescence and Apoptosis: Architects of Mammalian Development.Frontiers in cell and developmental biology · 2020Review
- Article
- Focus-ING on DNA Integrity: Implication of ING Proteins in Cell Cycle Regulation and DNA Repair Modulation.Cancers · 2019Review
- Biological Functions of the ING Proteins.Cancers · 2019Review
- Impaired DNA demethylation of C/EBP sites causes premature aging.Genes & development · 2018Article
- Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein.British journal of cancer · 2018Article
- The emerging role of alternative splicing in senescence and aging.Aging cell · 2017Review
- INGs are potential drug targets for cancer.Journal of cancer research and clinical oncology · 2017Review
- A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Ectopic expression of p33Oncology letters · 2015Article
- LincRNA-p21 acts as a mediator of ING1b-induced apoptosis.Cell death & disease · 2015Article
- Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis.Cell death discovery · 2015Article
- MiR-371-5p facilitates pancreatic cancer cell proliferation and decreases patient survival.PloS one · 2014Article
- Article
- ING1 and ING2: multifaceted tumor suppressor genes.Cellular and molecular life sciences : CMLS · 2013Review
- ING1 induces apoptosis through direct effects at the mitochondria.Cell death & disease · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
ING proteins have been proposed to alter chromatin structure and gene transcription to regulate numerous aspects of cell physiology, including cell growth, senescence, stress response, apoptosis, and transformation. ING1, the founding member of the inhibitor of growth family, encodes p37(Ing1), a plant homeodomain (PHD) protein that interacts with the p53 tumor suppressor protein and seems to be a critical cofactor in p53-mediated regulation of cell growth and apoptosis. In this study, we have generated and analyzed p37(Ing1)-deficient mice and primary cells to further explore the role of Ing1 in the regulation of cell growth and p53 activity. The results show that endogenous levels of p37(Ing1) inhibit the proliferation of p53-wild-type and p53-deficient fibroblasts, and that p53 functions are unperturbed in p37(Ing1)-deficient cells. In addition, loss of p37(Ing1) induces Bax expression and increases DNA damage-induced apoptosis in primary cells and mice irrespective of p53 status. Finally, p37(Ing1) suppresses the formation of spontaneous follicular B-cell lymphomas in mice. These results indicate that p53 does not require p37(Ing1) to negatively regulate cell growth and offers genetic proof that Ing1 suppresses cell growth and tumorigenesis. Furthermore, these data reveal that p37(Ing1) can negatively regulate cell growth and apoptosis in a p53-independent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.