GuidelineAnnals of the New York Academy of Sciences2007
Interpretation of oral fluid tests for drugs of abuse.
Guideline in Annals of the New York Academy of Sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.
- CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2022Guideline
- Design of the NIDA clinical trials network validation study of tobacco, alcohol, prescription medications, and substance use/misuse (TAPS) tool.Contemporary clinical trials · 2016Trial
- Considering unintentional exposure when testing for cocaine use via oral fluid testing.Forensic science international · 2026Article
- Simultaneous quantification of linezolid and its metabolites (PNU-142300 and PNU-142586) in oral fluid and capillary blood by UPLC-MS/MS: method validation and clinical application using non-invasive sampling techniques.Journal of translational medicine · 2026Article
- Opioid detection and quantification in plasma and oral fluid by LC-MS/MS.Analytical and bioanalytical chemistry · 2026Article
- Implementation outcomes of video-observed oral fluid self-collection for drug testing in substance use disorder treatment: a pilot study.Frontiers in public health · 2026Article
- Recent advances in the identification and quantification of xylazine and medetomidine in biological specimens.Bioanalysis · 2025Review
- Determination of drugs of abuse in oral fluid using dried oral fluid spot assisted by 24-well plate and LC-MS/MS.Bioanalysis · 2025Review
- Non-Invasive Point-of-Care Detection of Methamphetamine and Cocaine via Aptamer-Based Lateral Flow Test.Biosensors · 2025Article
- Article
- Stability of drugs of abuse in synthetic oral fluid investigated using a simple "dilute and inject" method of analysis.Drug testing and analysis · 2022Article
- Study of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) extraction FROM dried oral fluid spots (DOFS) and LC-MS/MS detection.Journal of cannabis research · 2021Article
- Feasibility of Using Oral Fluid for Therapeutic Drug Monitoring of Antiepileptic Drugs.European journal of drug metabolism and pharmacokinetics · 2021Review
- Salivary Bioscience and the Future of Behavioral Medicine.International journal of behavioral medicine · 2020Article
- Comparison of timeline follow-back self-report and oral fluid testing to detect substance use in adult primary care patients.Drug and alcohol dependence · 2020Article
- Opium Alkaloids in Harvested and Thermally Processed Poppy Seeds.Frontiers in chemistry · 2020Article
- Nicotine and cotinine in oral fluid: Passive exposure vs active smoking.Practical laboratory medicine · 2018Article
- A Novel Chronic Opioid Monitoring Tool to Assess Prescription Drug Steady State Levels in Oral Fluid.Pain medicine (Malden, Mass.) · 2017Article
- Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GC/MS.International journal of analytical chemistry · 2016Article
- A Brief Patient Self-administered Substance Use Screening Tool for Primary Care: Two-site Validation Study of the Substance Use Brief Screen (SUBS).The American journal of medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Oral fluid testing for drugs of abuse offers significant advantages over urine as a test matrix. Collection can be performed under direct observation with reduced risk of adulteration and substitution. Drugs generally appear in oral fluid by passive diffusion from blood, but also may be deposited in the oral cavity during oral, smoked, and intranasal administration. Drug metabolites also can be detected in oral fluid. Unlike urine testing, there may be a close correspondence between drug and metabolite concentrations in oral fluid and in blood. Interpretation of oral fluid results for drugs of abuse should be an iterative process whereby one considers the test results in the context of program requirements and a broad scientific knowledge of the many factors involved in determining test outcome. This review delineates many of the chemical and metabolic processes involved in the disposition of drugs and metabolites in oral fluid that are important to the appropriate interpretation of oral fluid tests. Chemical, metabolic, kinetic, and analytic parameters are summarized for selected drugs of abuse, and general guidelines are offered for understanding the significance of oral fluid tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.