ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
Neurodegeneration and cell replacement.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Laterality and sex differences in the expression of brain-derived neurotrophic factor in developing rat hippocampus.Metabolic brain disease · 2021Article
- Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus.Molecular neurobiology · 2019Review
- On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations.Frontiers in neurology · 2018Review
- Boundary Cap Neural Crest Stem Cells Promote Survival of Mutant SOD1 Motor Neurons.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Article
- Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders.Neuromolecular medicine · 2015Review
- Neuronal cell reconstruction with umbilical cord blood cells in the brain hypoxia-ischemia.Iranian biomedical journal · 2015Article
- Sex differences and laterality of insulin receptor distribution in developing rat hippocampus: an immunohistochemical study.Journal of molecular neuroscience : MN · 2014Article
- NK cells after transplantation: friend or foe.Immunologic research · 2014Review
- Gender differences and lateralization in the distribution pattern of insulin-like growth factor-1 receptor in developing rat hippocampus: an immunohistochemical study.Cellular and molecular neurobiology · 2014Article
- Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling.Frontiers in cellular neuroscience · 2014Article
- Natural killer cell-activating receptor NKG2D mediates innate immune targeting of allogeneic neural progenitor cell grafts.Stem cells (Dayton, Ohio) · 2013Article
- PPARγ activation prevents impairments in spatial memory and neurogenesis following transient illness.Brain, behavior, and immunity · 2013Article
- Proliferation zones in the axolotl brain and regeneration of the telencephalon.Neural development · 2013Article
- Article
- Cell- and gene-based therapeutic approaches for neurological deficits in mucopolysaccharidoses.Current pharmaceutical biotechnology · 2011Review
- Article
- Therapeutic potential of umbilical cord blood stem cells on brain damage of a model of stroke.Journal of cardiovascular and thoracic research · 2011Article
- Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells.Purinergic signalling · 2010Article
- Review
- Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches.BMB reports · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past decade has witnessed ground-breaking advances in human stem cell biology with scientists validating adult neurogenesis and establishing methods to isolate and propagate stem cell populations suitable for transplantation. These advances have forged promising strategies against human neurodegenerative diseases. For example, growth factor administration could stimulate intrinsic repair from endogenous neural stem cells, and cultured stem cells engineered into biopumps could be transplanted to deliver neuroprotective or restorative agents. Stem cells could also be transplanted to generate new neural elements that augment and potentially replace degenerating central nervous system (CNS) circuitry. Early efforts in neural tissue transplantation have shown that these strategies can improve functional outcome, but the ultimate success of clinical stem cell-based strategies will depend on detailed understanding of stem cell biology in the degenerating brain and detailed evaluation of their functional efficacy and safety in preclinical animal models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.