ArticleJournal of the American Society for Mass Spectrometry2007
Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes.
Article in Journal of the American Society for Mass Spectrometry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis.The Journal of biological chemistry · 2012Article
- Multiple ABC transporters are involved in the acquisition of petrobactin in Bacillus anthracis.Molecular microbiology · 2012Article
- Fragmentation of singly, doubly, and triply charged hydrogen deficient peptide radical cations in infrared multiphoton dissociation and electron induced dissociation.Journal of the American Society for Mass Spectrometry · 2012Article
- Formation of peptide radical cations (m+·) in electron capture dissociation of peptides adducted with group IIB metal ions.Journal of the American Society for Mass Spectrometry · 2011Article
- Ferric stability constants of representative marine siderophores: marinobactins, aquachelins, and petrobactin.Inorganic chemistry · 2009Article
- Characterization of phosphate-containing metabolites by calcium adduction and electron capture dissociation.Journal of the American Society for Mass Spectrometry · 2008Article
- Abundant b-type ions produced in electron capture dissociation of peptides without basic amino acid residues.Journal of the American Society for Mass Spectrometry · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Siderophores are high-affinity iron-chelating ligands produced by microorganisms to scavenge vital Fe(3+) from the environment. Thus, siderophores constitute potential therapeutic targets and their structural determination is important for exploiting their therapeutic value. Here, the virulence-associated siderophore petrobactin from Bacillus anthracis was characterized with electron capture dissociation (ECD). Fragmentation of doubly protonated petrobactin was investigated and compared to sustained off-resonance irradiation collision-activated dissociation (SORI CAD) and infrared multiphoton dissociation (IRMPD) of both the singly and doubly protonated species. These experiments demonstrate that ECD provides additional information (complementary bond cleavages) on the structure of petrobactin compared to both SORI CAD and IRMPD. Furthermore, complexes of petrobactin with divalent (Ca(2+), Fe(2+), and Co(2+)) and trivalent (Fe(3+) and Ga(3+)) metal cations were also subjected to SORI CAD and ECD. Again, most structural information was obtained from the ECD spectra. However, significant differences were found in both SORI CAD and ECD of metal complexes, dependent on the nature of the metal ion. Intriguingly, unique behavior, consistent with a recently proposed solution-phase structure, was observed for the highly preferred Fe(3+)-petrobactin complex.
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