ArticleThe Biochemical journal2007
Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin 2/VAMP2.
Article in The Biochemical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Increased Expression of α-Synuclein Impairs Trafficking of the Essential SNARE Protein Synaptobrevin-2.Journal of neurochemistry · 2026Article
- Gene expression levels of synaptic exocytosis regulator synaptophysin in the brain and the olfactory organ of anadromous salmon.Fish physiology and biochemistry · 2022Article
- SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling.Frontiers in molecular neuroscience · 2021Review
- Light-Activated ROS Production Induces Synaptic Autophagy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder.Neurobiology of disease · 2017Article
- The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis.Frontiers in synaptic neuroscience · 2016Review
- A Fine Balance of Synaptophysin Levels Underlies Efficient Retrieval of Synaptobrevin II to Synaptic Vesicles.PloS one · 2016Article
- The Sybtraps: control of synaptobrevin traffic by synaptophysin, α-synuclein and AP-180.Traffic (Copenhagen, Denmark) · 2014Review
- X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions.PloS one · 2012Article
- Mild traumatic brain injury (MTBI) leads to spatial learning deficits.Brain injury · 2012Article
- Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A fast and robust method for automated analysis of axonal transport.European biophysics journal : EBJ · 2011Article
- Maturation of neurotransmission in the developing rat cochlea: immunohistochemical evidence from differential expression of synaptophysin and synaptobrevin 2.European journal of histochemistry : EJH · 2011Article
- The genetic basis of non-syndromic intellectual disability: a review.Journal of neurodevelopmental disorders · 2010Article
- A model for sealing plasmalemmal damage in neurons and other eukaryotic cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Determination of axonal transport velocities via image cross- and autocorrelation.European biophysics journal : EBJ · 2009Article
- Synaptophysin as a probable component of neurotransmission occurring in taste receptor cells.Journal of molecular histology · 2009Article
- Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle.Genome biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Biogenesis and recycling of synaptic vesicles are accompanied by sorting processes that preserve the molecular composition of the compartments involved. In the present study, we have addressed the targeting of synaptobrevin 2/VAMP2 (vesicle-associated membrane protein 2), a critical component of the synaptic vesicle--fusion machinery, in a heterotypic context where its sorting is not confounded by the presence of other neuron-specific molecules. Ectopically expressed synaptophysin I interacts with VAMP2 and alters its default surface targeting to a prominent vesicular distribution, with no effect on the targeting of other membrane proteins. Protein-protein interaction is not sufficient for the control of VAMP2 sorting, which is mediated by the C-terminal domain of synaptophysin I. Synaptophysin I directs the sorting of VAMP2 to vesicles before surface delivery, without influencing VAMP2 endocytosis. Consistent with this, dynamin and alpha-SNAP (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein) mutants which block trafficking at the plasma membrane do not abrogate the effect of synaptophysin I on VAMP2 sorting. These results indicate that the sorting determinants of synaptic vesicle proteins can operate independently of a neuronal context and implicate the association of VAMP2 with synaptophysin I in the specification of the pathway of synaptic vesicle biogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.