ArticleBioconjugate chemistry
Peptidyl molecular imaging contrast agents using a new solid-phase peptide synthesis approach.
Article in Bioconjugate chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Heavy Metal Chelation and Bioprotective Activity of Dextran-DOTA Macromolecular Conjugate.Biomacromolecules · 2026Article
- Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes.Organic letters · 2019Article
- Detecting enzyme activities with exogenous MRI contrast agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Review
- Alternatives to gadolinium-based metal chelates for magnetic resonance imaging.Chemical reviews · 2010Review
- Advantages of macromolecular to nanosized chemical-exchange saturation transfer agents for MRI applications.Future medicinal chemistry · 2010Review
- An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis.Tetrahedron letters · 2009Article
- PARACEST properties of a dinuclear neodymium(III) complex bound to DNA or carbonate.Bioconjugate chemistry · 2009Article
- Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.Annual review of biomedical engineering · 2008Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A versatile method is disclosed for solid-phase peptide synthesis (SPPS) of molecular imaging contrast agents. A DO3A moiety was derivatized to introduce a CBZ-protected amino group and then coupled to a polymeric support. CBZ cleavage with Et2AlCl/thioanisole was optimized for SPPS. Amino acids were then coupled to the aminoDOTA-loaded resin using conventional stepwise Fmoc SPPS to create a product with DOTA coupled to the C-terminus of the peptide. In a second study, the DO3A moiety was coupled to a glycine-loaded polymeric support, and amino acids were then coupled to the amino-DOTA-peptide-loaded resin using SPPS to incorporate DOTA within the peptide sequence. The peptide-(Tm3+-DOTA) amide showed a paramagnetic chemical exchange saturation transfer (PARACEST) effect, which demonstrated the utility of this contrast agent for molecular imaging. These results demonstrate the advantages of exploiting SPPS methodologies through development of unique DOTA derivatives to create peptide-based molecular imaging contrast agents.
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Registered trials
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