ArticlePloS one2007
Tentative mapping of transcription-induced interchromosomal interaction using chimeric EST and mRNA data.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- It Is Imperative to Establish a Pellucid Definition of Chimeric RNA and to Clear Up a Lot of Confusion in the Relevant Research.International journal of molecular sciences · 2017Review
- ChimPipe: accurate detection of fusion genes and transcription-induced chimeras from RNA-seq data.BMC genomics · 2017Article
- Using chimaeric expression sequence tag as the reference to identify three-dimensional chromosome contacts.DNA research : an international journal for rapid publication of reports on genes and genomes · 2013Article
- Article
- Chromatin interaction networks and higher order architectures of eukaryotic genomes.Journal of cellular biochemistry · 2011Article
- Apparent non-canonical trans-splicing is generated by reverse transcriptase in vitro.PloS one · 2010Article
- Nuclear organization in the 3D space of the nucleus - cause or consequence?Current opinion in genetics & development · 2009Review
- Chromosome crosstalk in three dimensions.Nature · 2009Review
- Identifying protein-coding genes in genomic sequences.Genome biology · 2009Review
- Short homologous sequences are strongly associated with the generation of chimeric RNAs in eukaryotes.Journal of molecular evolution · 2009Article
- Identification and correction of abnormal, incomplete and mispredicted proteins in public databases.BMC bioinformatics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies on chromosome conformation show that chromosomes colocalize in the nucleus, bringing together active genes in transcription factories. This spatial proximity of actively transcribing genes could provide a means for RNA interaction at the transcript level. We have screened public databases for chimeric EST and mRNA sequences with the intent of mapping transcription-induced interchromosomal interactions. We suggest that chimeric transcripts may be the result of close encounters of active genes, either as functional products or "noise" in the transcription process, and that they could be used as probes for chromosome interactions. We have found a total of 5,614 chimeric ESTs and 587 chimeric mRNAs that meet our selection criteria. Due to their higher quality, the mRNA findings are of particular interest and we hope that they may serve as food for thought for specialists in diverse areas of molecular biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.