ArticlePloS one2007
Self-organization of anastral spindles by synergy of dynamic instability, autocatalytic microtubule production, and a spatial signaling gradient.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Branched microtubule nucleation and dynein transport organize RanGTP asters inMolecular biology of the cell · 2024Article
- Integrated model of the vertebrate augmin complex.Nature communications · 2023Article
- NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.Biology open · 2022Article
- How Microtubules Build the Spindle Branch by Branch.Annual review of cell and developmental biology · 2022Review
- Review
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- SAC3D1: a novel prognostic marker in hepatocellular carcinoma.Scientific reports · 2018Article
- Review
- Article
- Metaphase Spindle Assembly.Biology · 2017Review
- Article
- Mechanisms of Mitotic Spindle Assembly.Annual review of biochemistry · 2016Review
- Emergent Properties of the Metaphase Spindle.Cold Spring Harbor perspectives in biology · 2015Review
- Microtubule nucleation remote from centrosomes may explain how asters span large cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Microtubule networks for plant cell division.Systems and synthetic biology · 2014Review
- TPX2: of spindle assembly, DNA damage response, and cancer.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- Nucleating new branches from old.Cell · 2013Article
- The emergence of sarcomeric, graded-polarity and spindle-like patterns in bundles of short cytoskeletal polymers and two opposite molecular motors.Journal of physics. Condensed matter : an Institute of Physics journal · 2011Article
- Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assembly of the mitotic spindle is a classic example of macromolecular self-organization. During spindle assembly, microtubules (MTs) accumulate around chromatin. In centrosomal spindles, centrosomes at the spindle poles are the dominating source of MT production. However, many systems assemble anastral spindles, i.e., spindles without centrosomes at the poles. How anastral spindles produce and maintain a high concentration of MTs in the absence of centrosome-catalyzed MT production is unknown. With a combined biochemistry-computer simulation approach, we show that the concerted activity of three components can efficiently concentrate microtubules (MTs) at chromatin: (1) an external stimulus in form of a RanGTP gradient centered on chromatin, (2) a feed-back loop where MTs induce production of new MTs, and (3) continuous re-organization of MT structures by dynamic instability. The mechanism proposed here can generate and maintain a dissipative MT super-structure within a RanGTP gradient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.