ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Transgenic mouse lines subdivide medial vestibular nucleus neurons into discrete, neurochemically distinct populations.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 98 citations in OpenAlex.
- Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model.Nature communications · 2026Article
- Temporal dynamics of Purkinje cell-intrinsic excitability governs cerebellar systems consolidation.iScience · 2025Article
- Advanced progress of vestibular compensation in vestibular neural networks.CNS neuroscience & therapeutics · 2024Review
- Neonatal GABAergic transmission primes vestibular gating of output for adult spatial navigation.Cellular and molecular life sciences : CMLS · 2024Article
- A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep.iScience · 2024Article
- The Nature and Origin of Synaptic Inputs to Vestibulospinal Neurons in the Larval Zebrafish.eNeuro · 2023Article
- Parvalbumin-positive neurons in the medial vestibular nucleus contribute to vestibular compensation through commissural inhibition.Frontiers in cellular neuroscience · 2023Article
- Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome.Glia · 2022Article
- Perinatal development of central vestibular neurons in mice.Frontiers in neuroscience · 2022Article
- Monosynaptic targets of utricular afferents in the larval zebrafish.Frontiers in neurology · 2022Article
- Altered Synaptic Transmission and Excitability of Cerebellar Nuclear Neurons in a Mouse Model of Duchenne Muscular Dystrophy.Frontiers in cellular neuroscience · 2022Article
- Graded Coexpression of Ion Channel, Neurofilament, and Synaptic Genes in Fast-Spiking Vestibular Nucleus Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Histamine H1 Receptor Contributes to Vestibular Compensation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The statistics of the vestibular input experienced during natural self-motion differ between rodents and primates.The Journal of physiology · 2017Article
- Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance.Scientific reports · 2017Article
- Article
- Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.International journal of molecular medicine · 2016Article
- Responses of non-eye-movement central vestibular neurons to sinusoidal yaw rotation in compensated macaques after unilateral semicircular canal plugging.Journal of neurophysiology · 2016Article
- Glutamate and GABA in Vestibulo-Sympathetic Pathway Neurons.Frontiers in neuroanatomy · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The identification of neuron types within circuits is fundamental to understanding their relevance to behavior. In the vestibular nuclei, several classes of neurons have been defined in vivo on the basis of their activity during behavior, but it is unclear how those types correspond to neurons identified in slice preparations. By targeting recordings to neurons labeled in transgenic mouse lines, this study reveals that the continuous distribution of intrinsic parameters observed in medial vestibular nucleus (MVN) neurons can be neatly subdivided into two populations of neurons, one of which is GABAergic and the other of which is exclusively glycinergic or glutamatergic. In slice recordings, GABAergic neurons labeled in the EGFP (enhanced green fluorescent protein)-expressing inhibitory neuron (GIN) line displayed lower maximum firing rates (<250 Hz) than glycinergic and glutamatergic neurons labeled in the yellow fluorescent protein-16 (YFP-16) line (up to 500 Hz). In contrast to cortical and hippocampal interneurons, GABAergic MVN neurons exhibited wider action potentials than glutamatergic (and glycinergic) neurons. Responses to current injection differed between the neurons labeled in the two lines, with GIN neurons modulating their firing rates over a smaller input range, adapting less during steady depolarization, and exhibiting less rebound firing than YFP-16 neurons. These results provide a scheme for robust classification of unidentified MVN neurons by their physiological properties. Finally, dye labeling in slices shows that both GABAergic and glycinergic neurons project to the contralateral vestibular nuclei, indicating that commissural inhibition is accomplished through at least two processing streams with differential input and output properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.