Trial reportArchives of disease in childhood. Fetal and neonatal edition2007
Dopamine versus dobutamine in very low birthweight infants: endocrine effects.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Comparative efficacy of volume expansion, inotropes and vasopressors in preterm neonates with probable transitional circulatory instability in the first week of life: a systematic review and network meta-analysis.BMJ paediatrics open · 2024Pooled it
- European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism.The Journal of clinical endocrinology and metabolism · 2014Guideline
- A meta-analysis of dopamine use in hypotensive preterm infants: blood pressure and cerebral hemodynamics.Journal of perinatology : official journal of the California Perinatal Association · 2011Pooled it
- Feasibility study of early blood pressure management in extremely preterm infants.The Journal of pediatrics · 2012Trial
- Hemodynamic Assessment in Newborn Infants With Sepsis: A Prospective Observational Study.Cureus · 2026Article
- Rapid peptide analysis in dried bloodspots to identify novel markers for newborn screening for congenital hypothyroidism.Scientific reports · 2026Article
- The Quartile Levels of Thyroid-stimulating Hormone at Newborn Screening Stratified Risks of Neurodevelopmental Impairment in Extremely Preterm Infants: A Population Cohort Study.Journal of epidemiology · 2024Article
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- Correlation Between Thyroid Hormone Concentrations and Ultrasound Thyroid Volume in Preterm Infants Born Before 33 Weeks of Gestation.Frontiers in endocrinology · 2022Observational
- The factors associated with transient hypothyroxinemia of prematurity.BMC pediatrics · 2021Article
- Article
- Congenital hypothyroidism with delayed thyroid-stimulating hormone elevation in premature infants born at less than 30 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Nationwide Evaluation of Congenital Hypothyroidism Screening during Neonatal Extracorporeal Membrane Oxygenation.Neonatology · 2017Article
- Response to dopamine in prematurity: a biomarker for brain injury?Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence.World journal of clinical pediatrics · 2016Article
- A Literature Review of the Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates.Pediatric cardiology · 2016Review
- Heterogeneous phenotype in children affected by non-autoimmune hypothyroidism: an update.Journal of endocrinological investigation · 2015Review
- Challenges in Treating Low Blood Pressure in Preterm Infants.Children (Basel, Switzerland) · 2015Review
- The Italian screening program for primary congenital hypothyroidism: actions to improve screening, diagnosis, follow-up, and surveillance.Journal of endocrinological investigation · 2013Review
- Systematic Review and Meta-Analysis of Cardiovascular Medications in Neonatal Hypotension.Biomedicine hubArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the endocrine effects of dopamine and dobutamine in hypotensive very low birthweight (VLBW) infants.
designNon-blinded randomised prospective trial.
settingLevel III neonatal intensive care unit. PATIENTS: 35 hypotensive VLBW infants who did not respond to volume loading, assigned to receive dopamine or dobutamine. MEASUREMENTS: Haemodynamic variables and serum levels of thyroid stimulating hormone (TSH), total thyroxine (T(4)), prolactin (PRL) and growth hormone were assessed during the first 72 h of treatment and the first 72 h after stopping treatment.
resultsDemographic and clinical data did not significantly differ between the two groups. Necessary cumulative and mean drug doses and maximum infusion required to normalise blood pressure were significantly higher in the dobutamine than in the dopamine group (p<0.01). Suppression of TSH, T(4) and PRL was observed in dopamine-treated newborns from 12 h of treatment onwards, whereas levels of growth hormone reduced significantly only at 12 h and 36 h of treatment (p<0.01). TSH, T(4) and PRL rebound was observed from the first day onwards after stopping dopamine. Dobutamine administration did not alter the profile of any of the hormones and no rebound was observed after stopping treatment.
conclusionDopamine and dobutamine both increase the systemic blood pressure, though dopamine is more effective. Dopamine reduces serum levels of TSH, T(4) and PRL in VLBW infants but such suppression is quickly reversed after treatment is stopped. Further research is required to assess if short-term iatrogenic pituitary suppression has longer-term consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.