ArticleRespiratory research2007
Expression of Toll-like receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis.
Article in Respiratory research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Respiratory Syncytial Virus Elicits Glycolytic Metabolism in Pediatric Upper and Lower Airways.Viruses · 2025Article
- Comprehensive analysis reveals hub genes associated with immune cell infiltration in allergic rhinitis.World journal of otorhinolaryngology - head and neck surgery · 2023Article
- A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19.Narra J · 2022Review
- TLR9 and COVID-19: A Multidisciplinary Theory of a Multifaceted Therapeutic Target.Frontiers in pharmacology · 2020Article
- Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps.Scientific reports · 2018Article
- Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases.Allergo journal international · 2018Review
- A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification.Scientific reports · 2017Article
- Antigen-presenting epithelial cells can play a pivotal role in airway allergy.The Journal of allergy and clinical immunology · 2016Article
- Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice.Scientific reports · 2015Article
- Eosinophils regulate peripheral B cell numbers in both mice and humans.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients.PloS one · 2014Article
- Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells.PloS one · 2014Article
- Pattern-recognition receptors in human eosinophils.Immunology · 2012Review
- Article
- Nasal lavage natural killer cell function is suppressed in smokers after live attenuated influenza virus.Respiratory research · 2011Article
- Role of Toll-like Receptor 3 Variants in Aspirin-Exacerbated Respiratory Disease.Allergy, asthma & immunology research · 2011Article
- The expression and function of Nod-like receptors in neutrophils.Immunology · 2010Article
- Allergic rhinitis and genetic components: focus on Toll-like receptors (TLRs) gene polymorphism.The application of clinical genetics · 2010Article
- CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations.Clinical and molecular allergy : CMA · 2008Article
- Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells.American journal of rhinologyArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllergic rhinitis is an inflammatory disease of the upper airway mucosa that also affects leukocytes in bone marrow and peripheral blood. Toll-like receptor 9 (TLR9) is a receptor for unmethylated CpG dinucleotides found in bacterial and viral DNA. The present study was designed to examine the expression of TLR9 in the nasal mucosa and in leukocytes derived from different cellular compartments during symptomatic allergic rhinitis.
methodsThe study was based on 32 patients with seasonal allergic rhinitis and 18 healthy subjects, serving as controls. Nasal biopsies were obtained before and after allergen challenge. Bone marrow, peripheral blood and nasal lavage fluid were sampled outside and during pollen season. The expression of TLR9 in tissues and cells was analyzed using immunohistochemistry and flow cytometry, respectively.
resultsTLR9 was found in several cell types in the nasal mucosa and in different leukocyte subpopulations derived from bone marrow, peripheral blood and nasal lavage fluid. The leukocyte expression was generally higher in bone marrow than in peripheral blood, and not affected by symptomatic allergic rhinitis.
conclusionThe widespread expression of TLR9 in the nasal mucosa along with its rich representation in leukocytes in different compartments, demonstrate the possibility for cells involved in allergic airway inflammation to directly interact with bacterial and viral DNA.
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