ArticleActa veterinaria Scandinavica2007
Cardiac troponin I levels in canine pyometra.
Article in Acta veterinaria Scandinavica, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- High-Sensitive Cardiac Troponin I and Th1/Th2 Polarization in Queens With Pyometra.Veterinary medicine and science · 2025Article
- Effect of administering dexmedetomidine with or without atropine on cardiac troponin I level in isoflurane-anesthetized dogs.The Journal of veterinary medical science · 2021Article
- Electrocardiographic Findings in Bitches Affected by Closed Cervix Pyometra.Veterinary sciences · 2020Article
- Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis.BMC veterinary research · 2018Article
- Closed cervix is associated with more severe illness in dogs with pyometra.BMC veterinary research · 2017Article
- Serum cardiac troponin I concentrations in dogs with systemic inflammatory response syndrome.Journal of veterinary internal medicine · 2015Article
- Outcome of pyometra in female dogs and predictors of peritonitis and prolonged postoperative hospitalization in surgically treated cases.BMC veterinary research · 2014Article
- Concentrations of cardiac Troponin I before and after ovariohysterectomy in 46 female dogs with pyometra.Acta veterinaria Scandinavica · 2008Article
- Cardiac Troponins in Dogs and Cats.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyocardial injury may contribute to unexpected deaths due to pyometra. To detect myocardial damage, measurement of cardiac troponin I (cTnI) is currently the most sensitive and specific method. The aims of the present study were to evaluate presence of myocardial damage in canine pyometra by analysis of cTnI, to explore whether myocardial injury was associated with systemic inflammatory response syndrome (SIRS) and to evaluate whether other clinical or laboratory parameters were associated with cTnI increase.
methodsPreoperative plasma levels of cTnI were investigated in 58 female dogs with pyometra and 9 controls. The value of physical examination findings, haematological, serum biochemical and pro-inflammatory (CRP and TNF-alpha) parameters as possible predictors of increased cTnI levels was also evaluated.
resultsSeven dogs with pyometra (12%) and one control dog (11%) had increased levels of cTnI. In the pyometra group, the levels ranged between 0.3-0.9 microg l-1 and in the control dog the level was 0.3 microg l-1. The cTnI levels did not differ significantly between the two groups. No cardiac abnormalities were evident on preoperative physical examinations. Four of the pyometra patients died within two weeks of surgery, of which two were examined post mortem. In one of these cases (later diagnosed with myocarditis and disseminated bacterial infection) the cTnI levels increased from 0.9 microg l-1 preoperatively to 180 microg l-1 the following day when also heart arrhythmia was also detected. The other patient had cTnI levels of 0.7 microg l-1 with no detectable heart pathology post mortem. CTnI increase was not associated with presence of SIRS. There was a trend for the association of cTnI increase with increased mortality. No preoperative physical examination findings and few but unspecific laboratory parameters were associated with increased cTnI levels.
conclusionIncreased cTnI levels were observed in 12% of the dogs with pyometra. The proportions of dogs with cTnI increase did not differ significantly in the pyometra group compared with the control group. CTnI increase was not associated with presence of SIRS. A trend for association of cTnI increase and mortality was observed. Preoperative physical examination findings and included laboratory parameters were poor predictors of increased cTnI levels.
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