ReviewClinical pharmacokinetics2007
Pharmacokinetics and therapeutic drug monitoring of newer antiepileptic drugs during pregnancy and the puerperium.
Review in Clinical pharmacokinetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Prognosis of people with focal epilepsy treated with anti-seizure medications (ASMs): a narrative review of current evidence and future directions.BMJ neurology open · 2025Review
- Reproductive and fetal toxicity studies of histamine H3 receptor antagonist DL76 used in mice to prevent maximal electroshock-induced seizure.Frontiers in pharmacology · 2024Article
- Issues of Women with Epilepsy and Suitable Antiseizure Drugs.Journal of epilepsy research · 2023Review
- Management of Anti-Seizure Medications during Pregnancy: Advancements in The Past Decade.Pharmaceutics · 2022Review
- Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide.Therapeutic advances in neurological disorders · 2022Review
- Pregabalin treatment in a pregnant woman with glossopharyngeal neuralgia.Brazilian journal of otorhinolaryngology · 2020Article
- Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonistDrug design, development and therapy · 2018Article
- Use of Antiepileptic Drugs During Pregnancy: Evolving Concepts.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Management of epilepsy during pregnancy: an update.Therapeutic advances in neurological disorders · 2016Review
- Management of epilepsy during pregnancy: evidence-based strategies.Future neurology · 2015Article
- Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring.Journal of clinical psychopharmacology · 2014Review
- Long-term consequences after exposure to antiepileptic drugs in utero.Therapeutic advances in drug safety · 2011Review
- A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin.Clinical pharmacokinetics · 2010Review
- Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications.Pharmaceuticals (Basel, Switzerland) · 2010Article
- Pregnancy and epilepsy: what should we tell our patients?Journal of neurology · 2009Review
- Antiepileptic drugs during pregnancy: what is known and which AEDs seem to be safest?Epilepsia · 2008Review
- Pharmacokinetics and therapeutic drug monitoring of antiretrovirals in pregnant women.British journal of clinical pharmacology · 2008Review
- Tiagabine: efficacy and safety in partial seizures - current status.Neuropsychiatric disease and treatment · 2008Article
- Does oxcarbazepine warrant therapeutic drug monitoring? A critical review.Clinical pharmacokinetics · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of epilepsy in pregnancy is particularly challenging in that the fetal and maternal risks associated with maternal seizures need to be balanced against the potential teratogenic effects of antiepileptic drugs (AEDs). Pregnancy is known to affect the pharmacokinetics of older-generation AEDs. Understanding such alterations is important in the effort to optimise drug therapy since they may affect seizure control as well as fetal drug exposure. Therapeutic drug monitoring has therefore been recommended to control for changes in the disposition of the older-generation AEDs during pregnancy. Much less is known about gestation-induced alterations in the pharmacokinetics of the newer AEDs that have been introduced in the last 15 years. Lamotrigine is by far the most extensively studied of the newer AEDs. Pronounced alterations have been reported in the apparent clearance of lamotrigine, with an increase of >300% from baseline in late pregnancy in some patients on monotherapy, most likely due to enhanced metabolism. The available data suggest that the corresponding decline in plasma concentrations can be associated with loss of seizure control. More limited data indicate that a similar decline in plasma concentrations of the active monohydroxy derivative of oxcarbazepine may occur in late pregnancy. Preliminary experience also suggests that a significant fall in plasma concentrations of levetiracetam may occur during pregnancy. No systematic information is available on the pharmacokinetics during pregnancy of other newer AEDs (e.g. gabapentin, pregabalin, tiagabine, topiramate or zonisamide). Given the importance of maintaining optimal treatment of epilepsy during pregnancy, therapeutic drug monitoring appears to be justified for lamotrigine and oxcarbazepine in particular. Systematic studies of the effects of pregnancy on the pharmacokinetics of the other newer-generation AEDs are urgently needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.