ArticleActa histochemica et cytochemica2006
Survivin as a prognostic factor for osteosarcoma patients.
Article in Acta histochemica et cytochemica, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Prognostic Significance of Survivin Expression in Osteosarcoma Patients: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Potential Markers to Differentiate Uterine Leiomyosarcomas from Leiomyomas.International journal of medical sciences · 2024Review
- Article
- Expression of high mobility group box 1 protein predicts a poorer prognosis for patients with osteosarcoma.Oncology letters · 2016Article
- Inhibition of oleandrin on the proliferation show and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathway.Journal of experimental & clinical cancer research : CR · 2015Article
- The survivin suppressant YM155 reverses doxorubicin resistance in osteosarcoma.International journal of clinical and experimental medicine · 2015Article
- CCN2 enhances resistance to cisplatin-mediating cell apoptosis in human osteosarcoma.PloS one · 2014Article
- Article
- Prognostic factors for teenage and adult patients with high-grade osteosarcoma: an analysis of 240 patients.Medical oncology (Northwood, London, England) · 2013Article
- Immunohistochemical investigation of cell cycle and apoptosis regulators (survivin, β-catenin, p53, caspase 3) in canine appendicular osteosarcoma.BMC veterinary research · 2012Article
- Vitamin d receptor, retinoid x receptor, ki-67, survivin, and ezrin expression in canine osteosarcoma.Veterinary medicine international · 2012Article
- Detection of femtomolar level osteosarcoma-related gene via a chronocoulometric DNA biosensor based on nanostructure gold electrode.International journal of nanomedicine · 2012Article
- YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma.BMC cancer · 2011Article
- Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin.Investigational new drugs · 2011Article
- Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells.Journal of experimental & clinical cancer research : CR · 2011Article
- Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells.Investigational new drugs · 2010Article
- mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis.Medical oncology (Northwood, London, England) · 2010Article
- Prognostic significance of survivin expression in renal cell cancer and its correlation with radioresistance.Molecular and cellular biochemistry · 2010Article
- Biomarkers in Osteosarcoma.Expert opinion on medical diagnostics · 2009Article
- A review of clinical and molecular prognostic factors in osteosarcoma.Journal of cancer research and clinical oncology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurvivin is one of the apoptosis inhibitor genes and is rarely expressed in adult -tissues. However, survivin expression has been detected in various human cancers and -correlations have been recognized between the level of expression of this gene in tumors and prognosis. In this study, we investigated the correlations between survivin mRNA expression in osteosarcoma tissues and clinicopathological parameters.
methodsThere were 22 osteosarcoma patients in our hospital with paraffin-embedded -tissues which could be extracted from biopsy specimens. We used the RT-PCR method after extracting total RNA and conducted a densitometric analysis to determine the ratio of survivin relative to h-GAPDH as an internal marker.
resultsExpression of survivin mRNA was detected in all osteosarcoma samples. Patients with metastasis had high survivin mRNA levels in initial biopsy specimens (p<0.01). Moreover, there was a statistically significant difference in survivin mRNA expression between -patients with and without metastasis (p<0.01).
conclusionWe concluded that high levels of survivin mRNA expression suggest poor prognosis for osteosarcoma patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.