Evidence map›Paper›PMID 17327921›Full record

ArticlePloS one2007

Evidence for active maintenance of inverted repeat structures identified by a comparative genomic approach.

Guoyan Zhao, Kuan Y Chang, Katherine Varley, Gary D Stormo

Open access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guoyan ZhaoDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Kuan Y Chang
Katherine Varley
Gary D Stormo
Washington University in St. Louis · US

Funding

INSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCET32HG000045 · NHGRI · WASHINGTON UNIVERSITY · PI MICHAEL R BRENT, Barak A Cohen · 1997 to 2026
$8.4M
DNA PATTERN IDENTIFICATION AND ANALYSISR01HG000249 · NHGRI · WASHINGTON UNIVERSITY · PI STORMO, GARY D · 1990 to 2017
$5.6M
Regulatory modules: identification and verificationF32GM073444 · NIGMS · WASHINGTON UNIVERSITY · PI ZHAO, GUOYAN · 2005 to 2007
$104k
NHGRI NIH HHS 5 T32 HG000045-08NHGRI NIH HHS HG00249NHGRI NIH HHS R01 HG000249NHGRI NIH HHS T32 HG000045NIGMS NIH HHS 1 F32 GM73444-01NIGMS NIH HHS F32 GM073444
6 · The paper itself

Abstract

Inverted repeats have been found to occur in both prokaryotic and eukaryotic genomes. Usually they are short and some have important functions in various biological processes. However, long inverted repeats are rare and can cause genome instability. Analyses of C. elegans genome identified long, nearly-perfect inverted repeat sequences involving both divergently and convergently oriented homologous gene pairs and complete intergenic sequences. Comparisons with the orthologous regions from the genomes of C. briggsae and C. remanei show that the inverted repeat structures are often far more conserved than the sequences. This observation implies that there is an active mechanism for maintaining the inverted repeat nature of the sequences.

Indexed as

Comparative Genomic HybridizationEvolution, MolecularGenetic SpeciationAnimalsCaenorhabditisCaenorhabditis elegansDNA, HelminthDNA, IntergenicGene DuplicationGenomic InstabilityInverted Repeat SequencesPhylogenySequence AlignmentSequence Homology, Nucleic AcidSpecies SpecificityDNA, HelminthDNA, Intergenic

Identifiers

PMID17327921
PMCPMC1803023
OpenAlexW2132537157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.