ArticlePloS one2007
Control of signaling in a MAP-kinase pathway by an RNA-binding protein.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- RNA regulatory networks diversified through curvature of the PUF protein scaffold.Nature communications · 2015Article
- The RNA-binding protein Whi3 is a key regulator of developmental signaling and ploidy in Saccharomyces cerevisiae.Genetics · 2013Article
- The mRNA decay pathway regulates the expression of the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae.Genetics · 2012Article
- A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans.Developmental biology · 2012Article
- Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress.PloS one · 2010Article
- Genome-wide analysis of mRNA targets for Caenorhabditis elegans FBF, a conserved stem cell regulator.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum.The Journal of biological chemistry · 2008Article
- Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.PloS one · 2008Article
- Replicative aging in yeast: the means to the end.Annual review of cell and developmental biology · 2008Review
- Conserved regulation of MAP kinase expression by PUF RNA-binding proteins.PLoS genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Signaling-protein mRNAs tend to have long untranslated regions (UTRs) containing binding sites for RNA-binding proteins regulating gene expression. Here we show that a PUF-family RNA-binding protein, Mpt5, represses the yeast MAP-kinase pathway controlling differentiation to the filamentous form. Mpt5 represses the protein levels of two pathway components, the Ste7 MAP-kinase kinase and the Tec1 transcriptional activator, and negatively regulates the kinase activity of the Kss1 MAP kinase. Moreover, Mpt5 specifically inhibits the output of the pathway in the absence of stimuli, and thereby prevents inappropriate cell differentiation. The results provide an example of what may be a genome-scale level of regulation at the interface of signaling networks and protein-RNA binding networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.