ArticleActa histochemica et cytochemica2006
Interstitial cells of cajal are involved in neurotransmission in the gastrointestinal tract.
Article in Acta histochemica et cytochemica, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
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- Anti-LGI1-antibody autoimmune encephalitis as a neurological paraneoplastic syndrome associated with gastrointestinal stromal tumour: a case report.Postepy psychiatrii neurologii · 2025Article
- Advancing peristalsis deciphering in mouse small intestine by multi-parameter tracking.Communications biology · 2023Article
- Morphological changes in intraepithelial and stromal telocytes in Cyprinus carpio in response to salinity stress.Scientific reports · 2023Article
- Plasticity of colonic enteric nervous system following spinal cord injury in male and female rats.Neurogastroenterology and motility · 2023Article
- Neuroimmune regulation in Hirschsprung's disease associated enterocolitis.Frontiers in immunology · 2023Review
- Interstitial Cells of Cajal-Origin, Distribution and Relationship with Gastrointestinal Tumors.Medicina (Kaunas, Lithuania) · 2022Review
- Prediction of the Medicinal Mechanisms ofPlants (Basel, Switzerland) · 2022Article
- Grape seed powder increases gastrointestinal motility.International journal of medical sciences · 2022Article
- Nitric Oxide: From Gastric Motility to Gastric Dysmotility.International journal of molecular sciences · 2021Review
- Interstitial Cells of Cajal and Neural Structures in the Human Fetal Appendix.Journal of neurogastroenterology and motility · 2021Article
- Interstitial Cells of Cajal: Potential Targets for Functional Dyspepsia Treatment Using Medicinal Natural Products.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Fish telocytes and their relation to rodlet cells in ruby-red-fin shark (rainbow shark) Epalzeorhynchos frenatum (Teleostei: Cyprinidae).Scientific reports · 2020Article
- Morphological and immunohistochemical phenotype of TCs in the intestinal bulb of Grass carp and their potential role in intestinal immunity.Scientific reports · 2020Article
- Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility.International journal of molecular sciences · 2020Review
- Investigation of Novel c-Kit-expressing Smooth Muscle Cells in Murine Cecum.Acta histochemica et cytochemica · 2020Article
- A Close Relationship Between Networks of Interstitial Cells of Cajal and Gastrointestinal TransitFrontiers in pharmacology · 2020Article
- Interstitial cells of Cajal in WJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interstitial cells of Cajal (ICC) are important cells which coordinate gastrointestinal motility. ICC express Kit receptor tyrosine kinase, and Kit immunohistochemistry reveals ICC morphology and distribution in the gastrointestinal musculature. ICC show a highly branched morphology and form unique networks. Myenteric ICC (ICC-MY) are located at the layer of the myenteric plexus and serve as electrical pacemakers. Intramuscular ICC (ICC-IM) and ICC in the deep muscular plexus (ICC-DMP) are distributed within the muscular layers, and are densely innervated by excitatory and inhibitory enteric motor neurons and in close contact with nerve terminals. Recent studies combined with morphological and functional techniques directly revealed that ICC-IM and ICC-DMP are mediators of enteric motor neuro-transmission. These types of ICC express several receptors for neurotransmitters such as acetylcholine and substance P and show responses to excitatory nerve stimulations. ICC also express receptive mechanisms for nitric oxide, which is an inhibitory neurotransmitter in the gastrointestinal tract. They can respond to nitrergic nerve stimulation by cyclic GMP production. Kit mutant mice lack ICC-IM and show attenuated postsynaptic responses after intrinsic nerve stimulation. These findings indicate the importance for ICC in neurotransmission in the gastrointestinal tract.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.