ArticleMolecular and cellular biology1992
Heterogeneous nuclear ribonucleoprotein complexes and proteins in Drosophila melanogaster.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Predicted networks of protein-protein interactions in Stegodyphus mimosarum by cross-species comparisons.BMC genomics · 2017Article
- Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila.PLoS genetics · 2009Article
- Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Separable roles in vivo for the two RNA binding domains of Drosophila A1-hnRNP homolog.RNA (New York, N.Y.) · 1998Article
- Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo.Molecular biology of the cell · 1996Article
- RNA binding by Sxl proteins in vitro and in vivo.Molecular and cellular biology · 1994Article
- Essential role for a heterogeneous nuclear ribonucleoprotein (hnRNP) in oogenesis: hrp40 is absent from the germ line in the dorsoventral mutant squid.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- PUB1: a major yeast poly(A)+ RNA-binding protein.Molecular and cellular biology · 1993Article
- A unique ribonucleoprotein complex assembles preferentially on ecdysone-responsive sites in Drosophila melanogaster.Molecular and cellular biology · 1993Article
- Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock.Molecular and cellular biology · 1993Article
- The Rb97D gene encodes a potential RNA-binding protein required for spermatogenesis in Drosophila.Nucleic acids research · 1993Article
- Association of individual hnRNP proteins and snRNPs with nascent transcripts.The Journal of cell biology · 1993Article
- Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Pre-mRNAs cotranscriptionally associate with a small group of proteins to form heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. We have previously identified two genes in Drosophila melanogaster, Hrb98DE and Hrb87F (i.e., genes at 98DE and 87F encoding putative hnRNA binding proteins), which encode five protein species homologous to the mammalian A-B hnRNP proteins. The studies presented herein show that antibodies against the RNP domains of Hrb98DE reacted with 10 to 15 distinct spots of 38 to 40 kDa in the basic region of two-dimensional gels. These nuclear proteins bound single-stranded nucleic acids and were extracted from Drosophila tissue culture cells as 40 to 80S hnRNP complexes in association with 300 to 800 nucleotide fragments of RNA. The peak of poly(A)+ RNA sequences was coincident with the peak of HRB proteins in sucrose gradients, strongly suggesting that the HRB complexes identified are Drosophila hnRNP complexes. The repertoire of HRB proteins did not change significantly during embryogenesis and was similar to that observed in Drosophila tissue culture cells. Analyses with peptide-specific antisera demonstrated that the major proteins in the hnRNP complex were encoded by the two genes previously identified. Although the Drosophila HRB proteins are only approximately 60% identical throughout the RNP domains to the mammalian A-B hnRNP proteins, features of the basic pre-mRNA packaging mechanism appear to be highly conserved between D. melanogaster and mammals.
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