ArticleMolecular and cellular biology1992
The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 96 citations in OpenAlex.
- Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network.Integrative and comparative biology · 2024Review
- Paradoxical role of DNA methylation in activation of FoxA2 gene expression during endoderm development.The Journal of biological chemistry · 2014Article
- Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits.The Journal of clinical endocrinology and metabolism · 2014Article
- Article
- Foxa2-dependent hepatic gene regulatory networks depend on physiological state.Physiological genomics · 2009Article
- Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.Nucleic acids research · 2008Article
- Core transcriptional regulatory circuitry in human hepatocytes.Molecular systems biology · 2006Article
- Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.Molecular and cellular biology · 2003Article
- The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors.Nucleic acids research · 2001Article
- Adenovirus-mediated increase of HNF-3 levels stimulates expression of transthyretin and sonic hedgehog, which is associated with F9 cell differentiation toward the visceral endoderm lineage.Gene expression · 2001Article
- Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis.Molecular and cellular biology · 2000Article
- Liver enriched transcription factors and differentiation of hepatocellular carcinoma.Molecular pathology : MP · 1999Review
- Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes.Molecular and cellular biology · 1998Article
- The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression.Molecular and cellular biology · 1996Article
- The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family.Molecular and cellular biology · 1996Article
- Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1.Molecular and cellular biology · 1996Article
- Identification of a transthyretin enhancer site that selectively binds the hepatocyte nuclear factor-3 beta isoform.Gene expression · 1996Article
- Overproduction of a truncated hepatocyte nuclear factor 3 protein inhibits expression of liver-specific genes in hepatoma cells.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The transcription factor hepatocyte nuclear factor 3 (HNF-3) is involved in the coordinate expression of several liver genes. HNF-3 DNA binding activity is composed of three different liver proteins which recognize the same DNA site. The HNF-3 proteins (designated alpha, beta, and gamma) possess homology in the DNA binding domain and in several additional regions. To understand the cell-type-specific expression of HNF-3 beta, we have defined the regulatory sequences that elicit hepatoma-specific expression. Promoter activity requires -134 bp of HNF-3 beta proximal sequences and binds four nuclear proteins, including two ubiquitous factors. One of these promoter sites interacts with a novel cell-specific factor, LF-H3 beta, whose binding activity correlates with the HNF-3 beta tissue expression pattern. Furthermore, there is a binding site for the HNF-3 protein within its own promoter, suggesting that an autoactivation mechanism is involved in the establishment of HNF-3 beta expression. We propose that both the LF-H3 beta and HNF-3 sites play an important role in the cell-type-specific expression of the HNF-3 beta transcription factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.