ArticleVirology journal2007
Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses.
Article in Virology journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Thyroid hormone deficiency worsens outcomes in vaccinia virus infection.Journal of virology · 2025Article
- Poxviridae Pneumonia.Advances in experimental medicine and biology · 2024Review
- Lung type II alveolar epithelial cells collaborate with CCR2Nature communications · 2022Article
- Orally Administrated Recombinant Vaccinia Virus Displaying ROP4 Induces Protection againstVaccines · 2022Article
- Infection-Associated Thymic Atrophy.Frontiers in immunology · 2021Review
- Single Immunization of a Vaccine Vectored by a Novel Recombinant Vaccinia Virus Affords Effective Protection Against Respiratory Syncytial Virus Infection in Cotton Rats.Frontiers in immunology · 2021Article
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- Differential Response Following Infection of Mouse CNS with Virulent and Attenuated Vaccinia Virus Strains.Vaccines · 2019Article
- Vaccinia Virus C9 Ankyrin Repeat/F-Box Protein Is a Newly Identified Antagonist of the Type I Interferon-Induced Antiviral State.Journal of virology · 2018Article
- Review
- Review
- Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.Immunology · 2014Article
- Article
- Allergic airway disease in mice alters T and B cell responses during an acute respiratory poxvirus infection.PloS one · 2013Article
- CD8 T cells are essential for recovery from a respiratory vaccinia virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines.Biologicals : journal of the International Association of Biological Standardization · 2010Article
- Vaccinia virus vaccines: past, present and future.Antiviral research · 2009Review
- Virus entry by macropinocytosis.Nature cell biology · 2009Review
- Engineering the vaccinia virus L1 protein for increased neutralizing antibody response after DNA immunization.Virology journal · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRespiratory infection with the neurovirulent vaccinia virus (VV) strain Western Reserve (WR) results in an acute infection of the lung followed by dissemination of the virus to other organs and causes lethality in mice. The mechanisms of lethality are not well-understood. In this study, we analyzed virus replication and host immune responses after intranasal infection with lethal and non-lethal doses of VV using the WR strain and the less virulent Wyeth strain.
resultsThe WR strain replicated more vigorously in the lung and in the brain than the Wyeth strain. There were, however, no differences between the virus titers in the brains of mice infected with the higher lethal dose and the lower non-lethal dose of WR strain, suggesting that the amount of virus replication in the brain is unlikely to be the sole determining factor of lethality. The WR strain grew better in primary mouse lung cells than the Wyeth strain. Lethal infection with WR strain was associated with a reduced number of lymphocytes and an altered phenotype of the T cells in the lung compared to non-lethal infections with the WR or Wyeth strains. Severe thymus atrophy with a reduction of CD4 and CD8 double positive T cells was also observed in the lethal infection.
conclusionThese results suggest that the lethality induced by intranasal infection with a high dose of the WR strain is caused by the higher replication of virus in lung cells and immune suppression during the early phase of the infection, resulting in uncontrolled virus replication in the lung.
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Registered trials
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