ArticleJournal of neurology2007
Paraneoplastic diseases associated with thymoma.
Article in Journal of neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 90 citations in OpenAlex.
- Surgical outcomes of 215 patients with thymic epithelial tumors: A single-center experience.Thoracic cancer · 2020Trial
- Cixutumumab for patients with recurrent or refractory advanced thymic epithelial tumours: a multicentre, open-label, phase 2 trial.The Lancet. Oncology · 2014Trial
- Myasthenia Gravis and Thymoma.Muscle & nerve · 2026Review
- Case report: Thymoma-associated GAD65 autoimmunity: a unifying mechanism for multi-organ injury involving nervous, endocrine, and renal systems.Frontiers in immunology · 2026Article
- Case Report: Recurrent metastatic thymoma-associated multiple paraneoplastic syndromes: myasthenia gravis, dysgeusia, and acute intestinal pseudo-obstruction.Frontiers in oncology · 2026Article
- Article
- Thymoma-Induced Severe Biventricular Failure without Myasthenia Gravis: Investigating Tachycardia-Induced Cardiomyopathy.The American journal of case reports · 2025Article
- Biventricular Fatal Fulminant Myocarditis Infarct-Like Presentation in a Patient with Thymoma.Arquivos brasileiros de cardiologia · 2024Article
- Taste disorders and alopecia in myasthenia gravis.BMC neurology · 2024Article
- Thymoma-associated autoimmune encephalitis with myasthenia gravis: Case series and literature review.CNS neuroscience & therapeutics · 2024Review
- Autoimmunity in thymic epithelial tumors: a not yet clarified pathologic paradigm associated with several unmet clinical needs.Frontiers in immunology · 2024Review
- Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies.eNeurologicalSci · 2022Article
- Case report: Complex paraneoplastic syndromes in thymoma with nephrotic syndrome, cutaneous amyloidosis, myasthenia gravis, and Morvan's syndrome.Frontiers in oncology · 2022Article
- The efficacy and safety of immunotherapy in thymic epithelial tumors: more effective, more risky: a systematic review.Journal of thoracic disease · 2021Review
- Thymoma and Autoimmune Encephalitis: Clinical Manifestations and Antibodies.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Congenital thymoma.Autopsy & case reports · 2021Review
- Article
- Thymoma appearing 9 years after the resection of squamous cell carcinoma of the lip: A case report of triple primary tumors and literature review.Oncology letters · 2019Article
- Levels of Tc17 cells in thymic epithelial cell tumors associated with autoimmune diseases.Mediastinum (Hong Kong, China) · 2019Article
- Incidence and clinical variable inter-relationships of thymic epithelial tumors in northwest China.Journal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThymoma is frequently associated with paraneoplastic diseases (PDs), most commonly with myasthenia gravis (MG). This association is thought to depend on thymoma's capacity to produce and export T lymphocytes.
objective(1) To determine the frequency and characteristics of thymoma-associated PDs other than MG; (2) to evaluate T cell maturation in thymomas with and without PDs.
methodsWe studied 260 patients with thymoma (associated with MG in 228). The occurrence of PDs was monitored together with the tumor outcome. Phenotypic characterization of thymocyte subsets in 14 thymoma samples (7 with and 7 without MG) was performed by FACS.
resultsA total of 47 PDs was diagnosed in 41/260 patients (15.8 %). Neurological PDs included neuromyotonia, limbic encephalitis, polymyositis, subacute hearing loss, psychosis and sleep disorders. A broad spectrum of nonneurological PDs were observed, among these, hematological and cutaneous diseases prevailed. Like MG, these disorders occurred either in the presence of the thymoma or at different times after thymomectomy; their onset often heralded a tumor recurrence. In thymomas from MG subjects, we found an increased proportion of fully mature CD4 single positive (SP) thymocytes and a reduced frequency of CD4SPCD25(+) cells; the latter finding may reflect a deficient generation of T regulatory cells, a reduced intratumorous activation of T cells, or both.
conclusionsWe confirm the strong association of thymoma with PDs. These disorders often occurred in MG patients and their course in relation to thymoma was similar to that of MG. In accordance with previous observations, we found some alterations in the intratumorous production of mature CD4(+) T cells that could be involved in the pathogenesis of paraneoplastic autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.