SynthesisMolecular psychiatry2007
Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.
Synthesis in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
129 citing papers in PubMed, 5 syntheses or guidelines pooled it, 277 citations in OpenAlex.
- Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies.Molecular genetics & genomic medicine · 2018Pooled it
- COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation.Journal of psychiatry & neuroscience : JPN · 2013Pooled it
- A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.PloS one · 2012Pooled it
- Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis.Molecular psychiatry · 2010Pooled it
- Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies.Journal of psychiatry & neuroscience : JPN · 2009Pooled it
- Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.PloS one · 2016Trial
- The Influence of Catechol-O-Methyltransferase Val158Met Polymorphism in Cognitive Performance and Executive Functioning in Women with Migraine.Journal of clinical medicine · 2026Article
- Sex Differences on Social and Anxiety-Related Responses in Low-Density Lipoprotein Receptor Knockout Mice.Molecular neurobiology · 2026Article
- Associations between affective distress, alcohol use, and cognitive flexibility: moderating effects of COMT Val158Met genotype.Frontiers in public health · 2026Article
- Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.Neurobiology of aging · 2025Article
- Article
- Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease.Current research in translational medicine · 2024Article
- The Relationship between Executive Functions and Body Weight: Sex as a Moderating Variable.Behavioral sciences (Basel, Switzerland) · 2024Article
- Genetic bases of language control in bilinguals: Evidence from an EEG study.Human brain mapping · 2023Article
- Association ofFrontiers in psychiatry · 2023Article
- Genetic polymorphisms iniScience · 2022Article
- Parent-Adolescent Conflict, Depressive Symptoms, and Non-Suicidal Self-Injury among Chinese Adolescents: The Moderating Effect of the COMT Gene rs4680 Polymorphism.International journal of environmental research and public health · 2022Article
- Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory.Frontiers in human neuroscience · 2022Article
- Interacting Roles of COMT and GAD1 Genes in Patients with Treatment-Resistant Schizophrenia: a Genetic Association Study of Schizophrenia Patients and Healthy Controls.Journal of molecular neuroscience : MN · 2021Article
- Long acting aripiprazole influences cognitive functions in recent onset schizophrenia.Psychopharmacology · 2021Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The catechol-O-methyltransferase (COMT) Val(158)Met polymorphism is hypothesized to affect executive function in patient and control populations. Studies inconsistently report better performance on the Wisconsin Card Sort Test (WCST) in individuals with one or more Met alleles. We conducted a meta-analysis of studies published until August 2006 that reported WCST perseverative errors from healthy volunteers or patients with schizophrenia-spectrum disorders. Twelve studies met inclusion criteria (total n=1910) providing 10 samples each of patients and controls. In healthy controls, individuals with the Met/Met genotype performed better than those with the Val/Val genotype (d=0.29; 95% confidence interval (CI) 0.02-0.55; P=0.03), but this was not supported in the patient sample (d=-0.07; 95% CI -0.40 to 0.26; P=0.68). Post hoc analyses suggested that Val and Met alleles are codominant in their effects on cognition. Effect size was greater in studies published at an earlier date and may also be larger in non-Caucasian samples. Gender did not affect the results. There was no evidence of publication bias. We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.