ArticleInfection and immunity2007
Synthesis and characterization of a dipalmitoylated lipopeptide derived from paralogous lipoproteins of Mycoplasma pneumoniae.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Identification of Mycoplasma pneumoniae P1-interacting proteins by GST pull-down and analysis of its transcriptomic regulation in A549 cells.FEMS microbiology letters · 2026Article
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- Advances in adhesion-related pathogenesis inFrontiers in microbiology · 2025Review
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- Adhesion molecules: a way to understand lupus.Reumatologia · 2022Review
- Naringenin suppresses Toll-like receptor 2-mediated inflammatory responses through inhibition of receptor clustering on lipid rafts.Food science & nutrition · 2021Article
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- Characterization of an Immunoglobulin Binding Protein (IbpM) FromFrontiers in microbiology · 2020Article
- The Role of Lipoproteins in Mycoplasma-Mediated Immunomodulation.Frontiers in microbiology · 2018Article
- Interaction of Mycoplasma hominis PG21 with Human Dendritic Cells: Interleukin-23-Inducing Mycoplasmal Lipoproteins and Inflammasome Activation of the Cell.Journal of bacteriology · 2017Article
- Insights into the pathogenesis of Mycoplasma pneumoniae (Review).Molecular medicine reports · 2016Review
- Inflammation-inducing Factors of Mycoplasma pneumoniae.Frontiers in microbiology · 2016Review
- Macrophage-activating lipopeptide-2 requires Mal and PI3K for efficient induction of heme oxygenase-1.PloS one · 2014Article
- Diacylated lipopeptide from Mycoplasma synoviae mediates TLR15 induced innate immune responses.Veterinary research · 2013Article
- Vaccination of BALB/c mice with an avirulent Mycoplasma pneumoniae P30 mutant results in disease exacerbation upon challenge with a virulent strain.Infection and immunity · 2012Article
- Nickel alterations of TLR2-dependent chemokine profiles in lung fibroblasts are mediated by COX-2.American journal of respiratory cell and molecular biology · 2008Article
- Modulation of asthma and allergy by addressing toll-like receptor 2.Journal of occupational medicine and toxicology (London, England) · 2008Article
- Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses.Molecular and cellular biology · 2008Article
- Mycoplasma pneumoniae-derived lipopeptides induce acute inflammatory responses in the lungs of mice.Infection and immunity · 2008Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic analysis of Mycoplasma pneumoniae revealed the existence of a large number of putative lipoprotein genes compared with the numbers in other bacteria. However, the pathogenic roles of M. pneumoniae lipoproteins are still obscure. In this study, we synthesized a lipopeptide (designated M. pneumoniae paralogous lipoprotein 1 [MPPL-1]) in which an S-dipalmitoylglyceryl cysteine was coupled to a peptide with a consensus sequence of a putative paralogous lipoprotein group characteristic of M. pneumoniae. The cytokine-inducing activity of MPPL-1 in human monocytic cells was much weaker (approximately 700-fold weaker) than that of the known mycoplasmal S-dipalmitoylated lipopeptide FSL-1 or MALP-2. MPPL-1 required Toll-like receptor (TLR2) to activate NF-kappaB-dependent gene transcription in HEK293 cells, although a 1,000-fold-larger amount of MPPL-1 was needed to exert activity similar to that of FSL-1 in the cells. TLR2-mediated recognition of MPPL-1 was synergistically upregulated by TLR6 but not by TLR1 or TLR10, although the activity was still weak. In addition, MPPL-1 did not antagonize FSL-1 recognition in human monocytic cells and TLR2/TLR6-expressing HEK293 cells. Thus, these results suggest that there is preferential selective recognition of diacylated lipopeptides due to the magnitude of an affinity with TLR2 and TLR6 and the roles of increased paralogous lipoprotein genes of M. pneumoniae in evasion of TLR2 recognition.
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