ArticleBiophysical journal2007
Mathematical models of specificity in cell signaling.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
- Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data.Nature communications · 2025Article
- Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways.International journal of molecular sciences · 2024Review
- Comparisons of two receptor-MAPK pathways in a single cell-type reveal mechanisms of signalling specificity.Nature plants · 2024Article
- Specificity models in MAPK cascade signaling.FEBS open bio · 2023Review
- Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes.International journal of molecular sciences · 2023Review
- Inflammation: A New Look at an Old Problem.International journal of molecular sciences · 2022Review
- The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation.International journal of molecular sciences · 2021Review
- Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes).International journal of molecular sciences · 2021Review
- A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity.eLife · 2018Article
- Coupled feedback loops control the stimulus-dependent dynamics of the yeast transcription factor Msn2.The Journal of biological chemistry · 2017Article
- Combined genomic and structural analyses of a cultured magnetotactic bacterium reveals its niche adaptation to a dynamic environment.BMC genomics · 2016Article
- Can we believe the DAGs? A comment on the relationship between causal DAGs and mechanisms.Statistical methods in medical research · 2016Article
- Linear models of activation cascades: analytical solutions and coarse-graining of delayed signal transduction.Journal of the Royal Society, Interface · 2016Article
- Barcode Sequencing Screen Identifies SUB1 as a Regulator of Yeast Pheromone Inducible Genes.G3 (Bethesda, Md.) · 2016Article
- Crosstalk between pathways enhances the controllability of signalling networks.IET systems biology · 2016Article
- A technique for determining the signs of sensitivities of steady states in chemical reaction networks.IET systems biology · 2014Article
- Paradoxical results in perturbation-based signaling network reconstruction.Biophysical journal · 2014Article
- Tunable signal processing through a kinase control cycle: the IKK signaling node.Biophysical journal · 2013Article
- Identification of the molecular mechanisms for cell-fate selection in budding yeast through mathematical modeling.Biophysical journal · 2013Article
- The energy costs of insulators in biochemical networks.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Cellular signaling pathways transduce extracellular signals into appropriate responses. These pathways are typically interconnected to form networks, often with different pathways sharing similar or identical components. A consequence of this connectedness is the potential for cross talk, some of which may be undesirable. Indeed, experimental evidence indicates that cells have evolved insulating mechanisms to partially suppress "leaking" between pathways. Here we characterize mathematical models of simple signaling networks and obtain exact analytical expressions for two measures of cross talk called specificity and fidelity. The performance of several insulating mechanisms--combinatorial signaling, compartmentalization, the inhibition of one pathway by another, and the selective activation of scaffold proteins--is evaluated with respect to the trade-off between the specificity they provide and the constraints they place on the network. The effects of noise are also examined. The insights gained from this analysis are applied to understanding specificity in the yeast mating and invasive growth MAP kinase signaling network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.