ArticleBiophysical journal2007
Direct imaging of individual intrinsic hydration layers on lipid bilayers at Angstrom resolution.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 183 citations in OpenAlex.
- Local mapping of the nanoscale viscoelastic properties of fluid membranes by AFM nanorheology.Nature communications · 2025Article
- Sensing Hydration of Biomimetic Cell Membranes.Biosensors · 2021Article
- Article
- Self-assembly of glycerol monooleate with the antimicrobial peptide LL-37: a molecular dynamics study.RSC advances · 2020Article
- Direct Measurement of Plant Cellulose Microfibril and Bundles in Native Cell Walls.Frontiers in plant science · 2020Article
- AFM nanoindentation reveals decrease of elastic modulus of lipid bilayers near freezing point of water.Scientific reports · 2019Article
- Effects of Ionic Strength, Salt, and pH on Aggregation of Boehmite Nanocrystals: Tumbler Small-Angle Neutron and X-ray Scattering and Imaging Analysis.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Revealing How Alkali Cations Affect the Surface Reactivity of Stainless Steel in Alkaline Aqueous Environments.ACS omega · 2018Article
- Controlling the mechanoelasticity of model biomembranes with room-temperature ionic liquids.Biophysical reviews · 2018Article
- Multifrequency AFM reveals lipid membrane mechanical properties and the effect of cholesterol in modulating viscoelasticity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Quantitative comparison of wideband low-latency phase-locked loop circuit designs for high-speed frequency modulation atomic force microscopy.Beilstein journal of nanotechnology · 2018Article
- Distinct Protein Hydration Water Species Defined by Spatially Resolved Spectra of Intermolecular Vibrations.The journal of physical chemistry. B · 2017Article
- Ions Modulate Stress-Induced Nanotexture in Supported Fluid Lipid Bilayers.Biophysical journal · 2017Article
- Imaging modes of atomic force microscopy for application in molecular and cell biology.Nature nanotechnology · 2017Review
- Direct observation of the dynamics of single metal ions at the interface with solids in aqueous solutions.Scientific reports · 2017Article
- Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid.Journal of visualized experiments : JoVE · 2016Article
- Microscopy techniques for investigating the control of organic constituents on biomineralization.MRS bulletin · 2015Article
- Fluid interfacial nanoroughness measurement through the morphological characteristics of graphene.Biomicrofluidics · 2014Article
- Filming biomolecular processes by high-speed atomic force microscopy.Chemical reviews · 2014Review
- Models and measurements of energy-dependent quenching.Photosynthesis research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interactions between water and biological molecules have the potential to influence the structure, dynamics, and function of biological systems, hence the importance of revealing the nature of these interactions in relation to the local biochemical environment. We have investigated the structuring of water at the interface of supported dipalmitoylphosphatidylcholine bilayers in the gel phase in phosphate buffer solution using frequency modulation atomic force microscopy (FM-AFM). We present experimental results supporting the existence of intrinsic (i.e., surface-induced) hydration layers adjacent to the bilayer. The force versus distance curves measured between the bilayer and the AFM tip show oscillatory force profiles with a peak spacing of 0.28 nm, indicative of the existence of up to two hydration layers next to the membrane surface. These oscillatory force profiles reveal the molecular-scale origin of the hydration force that has been observed between two apposing lipid bilayers. Furthermore, FM-AFM imaging at the water/lipid interface visualizes individual hydration layers in three dimensions, with molecular-scale corrugations corresponding to the lipid headgroups. The results demonstrate that the intrinsic hydration layers are stable enough to present multiple energy barriers to approaching nanoscale objects, such as proteins and solvated ions, and are expected to affect membrane permeability and transport.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.