ArticleThe Journal of biological chemistry2007
Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Death-associated protein kinase 1: a double-edged sword in health and disease.Frontiers in immunology · 2025Review
- Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease.Translational neurodegeneration · 2024Review
- Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.International journal of biological sciences · 2022Article
- Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.Journal of pineal research · 2020Article
- Regulation of the Expression of DAPK1 by SUMO Pathway.Biomolecules · 2019Article
- Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer's Disease.Recent patents on anti-cancer drug discovery · 2019Review
- Evaluation of the prognostic and physiological functions of death associated protein kinase 1 in breast cancer.Oncology letters · 2018Article
- Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria.Nature communications · 2017Article
- Quantitative and correlation analysis of the DNA methylation and expression of DAPK in breast cancer.PeerJ · 2017Article
- Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy.Frontiers in molecular neuroscience · 2016Review
- Identification of Novel Death-Associated Protein Kinase 2 Interaction Partners by Proteomic Screening Coupled with Bimolecular Fluorescence Complementation.Molecular and cellular biology · 2016Article
- Protein-Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP).Molecular & cellular proteomics : MCP · 2015Article
- miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis.Inflammatory bowel diseases · 2015Article
- Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review).International journal of oncology · 2015Review
- Death associated protein kinases: molecular structure and brain injury.International journal of molecular sciences · 2013Review
- The therapeutic target Hsp90 and cancer hallmarks.Current pharmaceutical design · 2013Review
- Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.Pharmaceuticals (Basel, Switzerland) · 2011Review
- The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.The EMBO journal · 2010Article
- Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis.The Journal of biological chemistry · 2010Article
- Mind bomb 1 regulation of cFLIP interactions.American journal of physiology. Cell physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Death-associated protein kinase (DAPK) has been found associated with HSP90, and inhibition of HSP90 with 17-alkylamino-17-demethoxygeldanamycin reduced expression of DAPK. These results were extended to determine whether the degradation of DAPK in the absence of HSP90 activity is dependent on the ubiquitin-proteasome pathway. Our results show that treatment of cells with geldanamycin (GA) leads to degradation of DAPK, and this degradation is attenuated by the proteasome inhibitor, lactacystin. GA-induced DAPK degradation is also dependent on phosphorylation of DAPK at Ser(308), and the cellular levels of phospho(Ser(308))-DAPK dramatically increase in response to GA treatment. Expression of two distinct ubiquitin E3 ligases, carboxyl terminus of HSC70-interacting protein (CHIP) or DIP1/Mib1, enhanced DAPK degradation, and conversely, short interfering RNA depletion of either CHIP or DIP1/Mib1 attenuated DAPK degradation. In vitro ubiquitination assays confirmed that DAPK is targeted for ubiquitination by both CHIP and DIP. Consistent with these results, DAPK is found in two distinct immune complexes, one containing HSP90 and CHIP and a second complex containing only DIP1/Mib. Collectively, these results indicate that strict modulation of DAPK activities is critical for regulation of apoptosis and cellular homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.