ArticleCellular immunology2006
Class II MHC antigen presentation defect in neonatal monocytes is not correlated with decreased MHC-II expression.
Article in Cellular immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen.Seminars in immunopathology · 2017Review
- The innate immune response to lower respiratory tract E. Coli infection and the role of the CCL2-CCR2 axis in neonatal mice.Cytokine · 2017Article
- Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype.Immunology · 2017Article
- Role of innate immunity in neonatal infection.American journal of perinatology · 2013Review
- Characterization of MHC-II antigen presentation by B cells and monocytes from older individuals.Clinical immunology (Orlando, Fla.) · 2012Article
- Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Preserved MHC-II antigen processing and presentation function in chronic HCV infection.Cellular immunology · 2011Article
- Oligonucleotide microarray analysis of age-related gene expression profiles in miniature pigs.PloS one · 2011Article
- Preserved MHC class II antigen processing in monocytes from HIV-infected individuals.PloS one · 2010Article
- Differences in organ dysfunctions between neonates and older children: a prospective, observational, multicenter study.Critical care (London, England) · 2010Article
- Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling.Infection and immunity · 2009Article
- Interferon regulatory factor 8 mediates tumor-induced inhibition of antigen processing and presentation by dendritic cells.Cancer immunology, immunotherapy : CII · 2009Article
- Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation.PloS one · 2007Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Neonates are at increased risk of infections compared to adults. To dissect the mechanisms that contribute to neonatal immune deficiency, we compared MHC-II antigen processing and presentation by monocytes from umbilical cord blood and unrelated adult controls. Antigen-specific, co-stimulation-independent murine T hybridoma cells were used to detect peptide:HLA-DR complexes. Relative to adult monocytes, neonatal monocytes were significantly defective in processing and presentation of protein antigens and presentation of exogenous peptide. Defects in responses to protein antigens and exogenous peptide were of similar magnitude (56-81% decrease), indicating that the defect lies in antigen presentation as opposed to intracellular antigen processing. Average surface MHC-II levels on neonatal monocytes were 38% less than on adult monocytes. However, there was no correlation between decreased MHC-II expression on individual neonatal monocyte samples and reduced T cell responses. We demonstrate for the first time that neonatal monocytes are defective in MHC-II antigen presentation by a mechanism not correlated with decreased MHC-II expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.