ArticleVirology journal2007
Mechanisms regulating expression of the HPV 31 L1 and L2 capsid proteins and pseudovirion entry.
Article in Virology journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers.Infectious agents and cancer · 2025Review
- Papillomaviruses and Endocytic Trafficking.International journal of molecular sciences · 2018Review
- Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism.Journal of virology · 2017Article
- Host cell restriction factors that limit transcription and replication of human papillomavirus.Virus research · 2017Review
- Filopodia and Viruses: An Analysis of Membrane Processes in Entry Mechanisms.Frontiers in microbiology · 2016Review
- Article
- Review
- Human papillomavirus molecular biology and disease association.Reviews in medical virology · 2015Review
- Annexin A2 and S100A10 regulate human papillomavirus type 16 entry and intracellular trafficking in human keratinocytes.Journal of virology · 2013Article
- Human papillomavirus types 16, 18, and 31 share similar endocytic requirements for entry.Journal of virology · 2013Article
- Host-cell factors involved in papillomavirus entry.Medical microbiology and immunology · 2012Review
- Principles of polyoma- and papillomavirus uncoating.Medical microbiology and immunology · 2012Review
- LDP12, a novel cell-permeable peptide derived from L1 capsid protein of the human papillomavirus.Molecular biology reports · 2012Article
- Recent developments in the interactions between caveolin and pathogens.Advances in experimental medicine and biology · 2012Review
- Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis.PLoS pathogens · 2012Article
- Article
- The cytoskeleton in papillomavirus infection.Viruses · 2011Review
- Function of membrane rafts in viral lifecycles and host cellular response.Biochemistry research international · 2011Article
- Hijacking the endocytic machinery by microbial pathogens.Protoplasma · 2010Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Human papillomaviruses (HPV) infect stratified epithelia and restrict expression of late capsid genes to highly differentiated cells. In order to begin to understand the processes regulating HPV 31 infection we examined the synthesis of the HPV 31 capsid proteins, L1 and L2, using heterologous expression systems. Similar to studies in HPV 16, expression of wild type HPV 31 L1 and L2 from heterologous promoters resulted in very low levels of synthesis. In contrast, modification of the codons in the capsid genes to ones more commonly used in cellular genes resulted in high-level synthesis. Through the use of chimeric proteins that fused fragments of wild type L1 to Green Fluorescent Protein (GFP) coding sequences, a short region was identified that was sufficient to inhibit high level synthesis and similar elements were detected in L2. One element was localized to the 3' end of the L1 gene while a series of elements were localized at the 3' end of the L2 coding sequences. These observations are most consistent with negative RNA regulatory elements controlling the levels of L1 and L2 synthesis that are distinct from those identified in HPV 16. Expression vectors for the codon modified HPV 31 capsid proteins were then transfected together with GFP reporter plasmids to generate HPV 31 pseudoviruses. Infection of cells with HPV 31 pseudoviruses in the presence of the inhibitors, chlorpromazine, nystatin or methyl-beta-cyclodextrin, demonstrated that HPV 31, like HPV 16, enters human and monkey cells through a clathrin-mediated pathway rather than through caveolae as previously reported. This suggests that high-risk HPV types may enter cells through common mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.