ArticleBMC cardiovascular disorders2007
Mild hypothermia reduces cardiac post-ischemic reactive hyperemia.
Article in BMC cardiovascular disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Hypothermia in patients with acute myocardial infarction: a meta-analysis of randomized trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Pooled it
- Effectiveness of local cooling for enhancing tissue ischemia tolerance in people with spinal cord injury.The journal of spinal cord medicine · 2013Trial
- Article
- Mild hypothermia attenuates ischaemia/reperfusion injury: insights from serial non-invasive pressure-volume loops.Cardiovascular research · 2023Article
- Therapeutic hypothermia for acute myocardial infarction: a narrative review of evidence from animal and clinical studies.Korean journal of anesthesiology · 2022Review
- Effects of Therapeutic Hypothermia on Normal and Ischemic Heart.Frontiers in cardiovascular medicine · 2021Review
- Real-time quantitative monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest with targeted temperature management.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Setting Up an Efficient Therapeutic Hypothermia Team in Conscious ST Elevation Myocardial Infarction Patients: A UK Heart Attack Center Experience.Therapeutic hypothermia and temperature management · 2015Article
- Coronary versus carotid blood flow and coronary perfusion pressure in a pig model of prolonged cardiac arrest treated by different modes of venoarterial ECMO and intraaortic balloon counterpulsation.Critical care (London, England) · 2012Article
- Mild hypothermia markedly reduces ischemia related coronary t-PA release.Journal of thrombosis and thrombolysis · 2010Article
- Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size.BMC cardiovascular disorders · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn experimentally induced myocardial infarction, mild hypothermia (33-35 degrees C) is beneficial if applied prior to ischemia or reperfusion. Hypothermia, when applied after reperfusion seems to confer little or no benefit. The mechanism by which hypothermia exerts its cell-protective effect during cardiac ischemia remains unclear. It has been hypothesized that hypothermia reduces the reperfusion damage; the additional damage incurred upon the myocardium during reperfusion. Reperfusion results in a massive increase in blood flow, reactive hyperemia, which may contribute to reperfusion damage. We postulated that hypothermia could attenuate the post-ischemic reactive hyperemia.
methodsSixteen 25-30 kg pigs, in a closed chest model, were anesthetized and temperature was established in all pigs at 37 degrees C using an intravascular cooling catheter. The 16 pigs were then randomized to hypothermia (34 degrees C) or control (37 degrees C). The left main coronary artery was then catheterized with a PCI guiding catheter. A Doppler flow wire was placed in the mid part of the LAD and a PCI balloon was then positioned proximal to the Doppler wire but distal to the first diagonal branch. The LAD was then occluded for ten minutes in all pigs. Coronary blood flow was measured before, during and after ischemia/reperfusion.
resultsThe peak flow seen during post-ischemic reactive hyperemia (during the first minutes of reperfusion) was significantly reduced by 43 % (p < 0.01) in hypothermic pigs compared to controls.
conclusionMild hypothermia significantly reduces post-ischemic hyperemia in a closed chest pig model. The reduction of reactive hyperemia during reperfusion may have an impact on cardiac reperfusion injury.
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Registered trials
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