ReviewAllergy2007
Mechanisms of virus-induced asthma exacerbations: state-of-the-art. A GA2LEN and InterAirways document.
Review in Allergy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Pooled it
- Atopic characteristics of wheezing children and responses to prednisolone.Pediatric pulmonology · 2007Trial
- In Vitro Effects of 5-Lipoxygenase Pathway Inhibition on Rhinovirus-Associated Bronchial Epithelial Inflammation.Pulmonary therapy · 2021Article
- Current Grand Challenges in Allergy.Frontiers in allergy · 2020Article
- Rhinovirus Species-Specific Antibodies Differentially Reflect Clinical Outcomes in Health and Asthma.American journal of respiratory and critical care medicine · 2018Article
- Article
- Synergistic Effect of Dermatophagoides farinae and Lipopolysaccharides in Human Middle ear Epithelial Cells.Allergy, asthma & immunology research · 2016Article
- Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice.Scientific reports · 2016Article
- Evaluation of functional, autonomic and inflammatory outcomes in children with asthma.World journal of clinical cases · 2015Review
- Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.The World Allergy Organization journal · 2015Article
- Effects of rhinovirus species on viral replication and cytokine production.The Journal of allergy and clinical immunology · 2014Article
- Association of hospitalizations for asthma with seasonal and pandemic influenza.Respirology (Carlton, Vic.) · 2014Article
- High degree of overlap between responses to a virus and to the house dust mite allergen in airway epithelial cells.PloS one · 2014Article
- Research needs in allergy: an EAACI position paper, in collaboration with EFA.Clinical and translational allergy · 2012Article
- House dust allergy and immunotherapy.Human vaccines & immunotherapeutics · 2012Article
- Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma.Immunologic research · 2012Review
- Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features.Clinical and translational allergy · 2012Article
- Infection, eosinophilia and childhood asthma.Asia Pacific allergy · 2012Article
- The airway epithelium: soldier in the fight against respiratory viruses.Clinical microbiology reviews · 2011Review
- The ABCs of rhinoviruses, wheezing, and asthma.Journal of virology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 15 institutions in 10 countries.
Funding
Abstract
Viral infections of the respiratory tract are the most common precipitants of acute asthma exacerbations. Exacerbations are only poorly responsive to current asthma therapies and new approaches to therapy are needed. Viruses, most frequently human rhinoviruses (RV), infect the airway epithelium, generate local and systemic immune responses, as well as neural responses, inducing inflammation and airway hyperresponsiveness. Using in vitro and in vivo experimental models the role of various proinflammatory or anti-inflammatory mediators, antiviral responses and molecular pathways that lead from infection to symptoms has been partly unravelled. In particular, mechanisms of susceptibility to viral infection have been identified and the bronchial epithelium appeared to be a key player. Nevertheless, additional understanding of the integration between the diverse elements of the antiviral response, especially in the context of allergic airway inflammation, as well as the interactions between viral infections and other stimuli that affect airway inflammation and responsiveness may lead to novel strategies in treating and/or preventing asthma exacerbations. This review presents the current knowledge and highlights areas in need of further research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.