Trial reportJournal of clinical periodontology2007
A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers.
Trial report in Journal of clinical periodontology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Immunomodulation as a novel treatment strategy for periodontal disease: a systematic review.BMC oral health · 2026Pooled it
- Systematic review and meta-analysis on the adjunctive use of host immune modulators in non-surgical periodontal treatment in healthy and systemically compromised patients.Scientific reports · 2021Pooled it
- The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review.Journal of environmental and public health · 2018Pooled it
- Matrix Metalloproteinase Inhibitors and Their Potential Clinical Application in Periodontitis.Diseases (Basel, Switzerland) · 2025Review
- Selective Antimicrobial Therapies for Periodontitis: Win the "Battle and the War".International journal of molecular sciences · 2021Review
- Periodontal therapeutics: Current host-modulation agents and future directions.Periodontology 2000 · 2020Review
- The tobacco-using periodontal patient: role of the dental practitioner in tobacco cessation and periodontal disease management.Periodontology 2000 · 2016Review
- Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts.Periodontology 2000 · 2013Review
- Multilevel analysis of clinical parameters in chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results.Journal of oral microbiology · 2012Article
- Antimicrobial or subantimicrobial antibiotic therapy as an adjunct to the nonsurgical periodontal treatment: a meta-analysis.ISRN dentistry · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
aimTobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non-surgical periodontal therapy. MATERIAL AND
methodsThis was a parallel arm, randomized, identical placebo-controlled trial with masking of examiner, care-giver, participant and statistician and 6 months of follow-up. Patients received non-surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling.
resultsEighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level -0.19 mm/month (95% CI=-0.34, 0.04; p=0.012) and probing depth 0.30 mm/month (95% CI=-0.42, -0.17; p<0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months.
conclusionsThis study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.