ArticleJournal of materials science. Materials in medicine2007
In vivo evaluation of an injectable Macroporous Calcium Phosphate Cement.
Article in Journal of materials science. Materials in medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Treatment of critical bone defects using calcium phosphate cement and mesoporous bioactive glass providing spatiotemporal drug delivery.Bioactive materials · 2023Article
- Sudoku of porous, injectable calcium phosphate cements - Path to osteoinductivity.Bioactive materials · 2022Review
- Review
- Fast dissolving glucose porogens for early calcium phosphate cement degradation and bone regeneration.Biomedical materials (Bristol, England) · 2020Article
- Risedronate-Loaded Macroporous Gel Foam Enriched with Nanohydroxyapatite: Preparation, Characterization, and Osteogenic Activity Evaluation Using Saos-2 Cells.AAPS PharmSciTech · 2019Article
- Recent Advances in Laser-Ablative Synthesis of Bare Au and Si Nanoparticles and Assessment of Their Prospects for Tissue Engineering Applications.International journal of molecular sciences · 2018Review
- Antimicrobial Hydroxyapatite-Gelatin-Silica Composite Pastes with Tunable Setting Properties.Journal of materials chemistry. B · 2017Article
- A New Biphasic Dicalcium Silicate Bone Cement Implant.Materials (Basel, Switzerland) · 2017Article
- 3D micro-CT analysis of void formations and push-out bonding strength of resin cements used for fiber post cementation.The journal of advanced prosthodontics · 2016Article
- Brushite foams--the effect of Tween® 80 and Pluronic® F-127 on foam porosity and mechanical properties.Journal of biomedical materials research. Part B, Applied biomaterials · 2016Article
- Assessment of injectable and cohesive nanohydroxyapatite composites for biological functions.Progress in biomaterials · 2015Article
- In Vivo Osteogenic Potential of Biomimetic Hydroxyapatite/Collagen Microspheres: Comparison with Injectable Cement Pastes.PloS one · 2015Article
- Nanostructured platforms for the sustained and local delivery of antibiotics in the treatment of osteomyelitis.Critical reviews in therapeutic drug carrier systems · 2015Review
- In vivo performance of novel soybean/gelatin-based bioactive and injectable hydroxyapatite foams.Acta biomaterialia · 2015Article
- Self-setting calcium orthophosphate formulations.Journal of functional biomaterials · 2013Article
- Influence of particle size on hardening and handling of a premixed calcium phosphate cement.Journal of materials science. Materials in medicine · 2013Article
- Recent developments of functional scaffolds for craniomaxillofacial bone tissue engineering applications.TheScientificWorldJournal · 2013Review
- Strategies towards injectable, load-bearing materials for the intervertebral disc: a review and outlook.Journal of materials science. Materials in medicine · 2013Review
- Polymeric additives to enhance the functional properties of calcium phosphate cements.Journal of tissue engineering · 2012Article
- Self-hardening calcium deficient hydroxyapatite/gelatine foams for bone regeneration.Journal of materials science. Materials in medicine · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Calcium Phosphate Cements (CPC) are highly biocompatible and osteconductive materials, its resorption rate still remains too slow for some applications. In this work the introduction of Macroporosity in an injectable CPC is evaluated as a way to accelerate resorption and to increase bone ingrowth. A Macroporous and a standard CPC were injected just after preparation in a defect drilled in rabbit femur for their in vivo evaluation. The foaming agent used was Albumen, which gave up to a 75% porosity. Sodium Alginate was added to promote the cohesion of the foamed paste after implantation. In the case of the Macroporous Cement, bone growth and neovascularisation was observed inside the pores of the material, not only at the margins of the cement but also in some central pores. After 12 weeks of implantation, the residual material volume of the Macroporous Cement was approximately 35% of the initial value, whereas only the outer layers of non-Macroporous CPC were resorbed, being the residual material volume close to 100%. The higher resorption rate was due to the higher surface contact with body fluids which increased the dissolution rate, and to the enhancement of the cellular activity.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.