ArticleJournal of materials science. Materials in medicine2007
Osteogenic properties of calcium phosphate ceramics and fibrin glue based composites.
Article in Journal of materials science. Materials in medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- A neurovascularized bone regeneration strategy for mandibular and alveolar bone defects based on elastin-like biomaterials.Regenerative biomaterials · 2026Article
- Fibrinogen-Induced Regeneration Sealing Technique (F.I.R.S.T.): A Retrospective Clinical Study on 105 Implants with a 3-7-Year Follow-Up.Journal of clinical medicine · 2024Article
- Restoring Facial Contour and Harmony Using Biphasic Calcium Phosphate Bioceramics.Plastic and reconstructive surgery. Global open · 2021Article
- Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion.BioMed research international · 2019Review
- Heterotopic bone formation in the musculus latissimus dorsi of sheep using β-tricalcium phosphate scaffolds: evaluation of different seeding techniques.Regenerative biomaterials · 2018Article
- Multimodal pore formation in calcium phosphate cements.Journal of biomedical materials research. Part A · 2018Article
- Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria.BioMed research international · 2017Article
- Comparison and preparation of multilayered polylactic acid fabric strengthen calcium phosphate-based bone substitutes for orthopedic applications.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2016Article
- Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model.Materials (Basel, Switzerland) · 2016Article
- Combining mesenchymal stem cell sheets with platelet-rich plasma gel/calcium phosphate particles: a novel strategy to promote bone regeneration.Stem cell research & therapy · 2015Article
- Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications.Journal of functional biomaterials · 2015Review
- Novel implantable composite biomaterial by fibrin glue and amniotic membrane for ocular surface reconstruction.Journal of materials science. Materials in medicine · 2015Article
- In Vivo Osteogenic Potential of Biomimetic Hydroxyapatite/Collagen Microspheres: Comparison with Injectable Cement Pastes.PloS one · 2015Article
- Winner for outstanding research in the Ph.D. category for the 2013 Society for Biomaterials meeting and exposition, April 10-13, 2013, Boston, Massachusetts: Osteogenic differentiation of adipose-derived and marrow-derived mesenchymal stem cells in modular protein/ceramic microbeads.Journal of biomedical materials research. Part A · 2013Article
- Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications.International journal of nanomedicine · 2013Review
- Biphasic bone substitute and fibrin sealant for treatment of benign bone tumours and tumour-like lesions.International orthopaedics · 2012Article
- Tissue adhesives in otorhinolaryngology.GMS current topics in otorhinolaryngology, head and neck surgery · 2009Article
- Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium phosphate (Ca-P) ceramics are currently used in various types of orthopaedic and maxillofacial applications because of their osteoconductive properties. Fibrin glue is also used in surgery due to its haemostatic, chemotactic and mitogenic properties and also as scaffolds for cell culture and transplantation. In order to adapt to surgical sites, bioceramics are shaped in blocks or granules and preferably in porous forms. Combining these bioceramics with fibrin glue provides a mouldable and self-hardening composite biomaterial. The aim of this work is to study the osteogenic properties of this composite material using two different animal models. The formation of newly formed bone (osteoinduction) and bone healing capacity (osteconduction) have been study in the paravertebral muscles of sheep and in critical sized defects in the femoral condyle of rabbits, respectively. The different implantations sites were filled with composite material associating Ca-P granules and fibrin glue. Ca-P granules of 1-2 mm were composed with 60% of hydroxyapatite and 40% of beta tricalcium phosphate in weight. The fibrin glue was composed of fibrinogen, thrombin and other biological factors. After both intramuscular or intraosseous implantations for 24 weeks and 3, 6, 12 and 24 weeks, samples were analyzed using histology and histomorphometry and mechanical test. In all cases, the newly formed bone was observed in close contact and around the ceramic granules. Depending on method of quantification, 6.7% (with BSEM) or 17% (with micro CT) of bone had formed in the sheep muscles and around 40% in the critical sized bone rabbit defect after 24 weeks. The Ca-P/fibrin material could be used for filling bone cavities in various clinical indications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.