ArticleJournal of materials science. Materials in medicine2007
Influence of porosity and fibre diameter on the degradation of chitosan fibre-mesh scaffolds and cell adhesion.
Article in Journal of materials science. Materials in medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The effectiveness of chitosan as a hemostatic in dentistry in patients with antiplatelet/anticoagulant therapy: systematic review with meta-analysis.BMC oral health · 2024Pooled it
- Multifunctional Electrospun PCL/Starch/n-AlInternational journal of molecular sciences · 2026Article
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- Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior.Advanced healthcare materials · 2025Review
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- Mechanical Properties of Lightweight Cementitious Cellular Composites Incorporating Micro-Encapsulated Phase Change Material.Materials (Basel, Switzerland) · 2021Article
- Article
- Review
- Fabrication of Multi-Layered Lidocaine and Epinephrine-Eluting PLGA/Collagen Nanofibers: In Vitro and In Vivo Study.Polymers · 2017Article
- Properties and in vitro characterization of polyhydroxybutyrate-chitosan scaffolds prepared by modified precipitation method.Journal of materials science. Materials in medicine · 2014Article
- Effectiveness of Hemcon Dental Dressing versus Conventional Method of Haemostasis in 40 Patients on Oral Antiplatelet Drugs.Sultan Qaboos University medical journal · 2012Article
- Optimization, characterization, and efficacy evaluation of 2% chitosan scaffold for tissue engineering and wound healing.Journal of pharmacy & bioallied sciencesArticle
- Efficacy of Platelet Rich Fibrin versus chitosan as a hemostatic agent following dental extraction in patients on antiplatelet therapy.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The state of the art approaches for tailoring the degradation of chitosan scaffolds are based on altering the chemical structure of the polymer. Nevertheless, such alterations may lead to changes in other properties of scaffolds, such as the ability to promote cell adhesion. The aim of this study was to investigate the influence of physical parameters such as porosity and fibre diameter on the degradation of chitosan fibre-mesh scaffolds, as a possible way of tailoring the degradation of such scaffolds. Four sets of scaffolds with distinct fibre diameter and porosity were produced and their response to degradation and cell adhesion was studied. The degradation study was carried out at 37degrees C in a lysozyme solution for five weeks. The extent of degradation was expressed as percentage of weight loss of the dried scaffolds after lysozyme treatment. Cell adhesion was assessed by Confocal Microscopy. The results have shown that the scaffolds with higher porosity degrade faster and that, within the same range of porosity, the fibres with smaller diameter degrade slightly faster. Furthermore, the morphological differences between the scaffolds did not affect the degree of cell adhesion, and the cells were observed throughout the thickness of all four types of scaffolds.
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Registered trials
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