ReviewJournal of mammary gland biology and neoplasia2007
The molecular culprits underlying precocious mammary gland involution.
Review in Journal of mammary gland biology and neoplasia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Molecular Regulatory Mechanisms of Mammary Gland Development: A Review.Animals : an open access journal from MDPI · 2025Review
- Differential ER stress responses during lactation and postpartum outcomes in mice depending on their mitochondrial genotype.Nature communications · 2025Article
- Review
- Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.Reproductive toxicology (Elmsford, N.Y.) · 2022Review
- Exposure to Propylparaben During Pregnancy and Lactation Induces Long-Term Alterations to the Mammary Gland in Mice.Endocrinology · 2021Article
- Mammary Stem Cells in Domestic Animals: The Role of ROS.Antioxidants (Basel, Switzerland) · 2018Review
- Oxybenzone Alters Mammary Gland Morphology in Mice Exposed During Pregnancy and Lactation.Journal of the Endocrine Society · 2018Article
- Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Article
- Genetic variants in mammary development, prolactin signalling and involution pathways explain considerable variation in bovine milk production and milk composition.Genetics, selection, evolution : GSE · 2014Article
- Cellular calcium dynamics in lactation and breast cancer: from physiology to pathology.American journal of physiology. Cell physiology · 2014Review
- Article
- Mouse mammary gland is refractory to the effects of ethanol after natural lactation.Comparative medicine · 2013Article
- Article
- Reactive oxygen species initiate luminal but not basal cell death in cultured human mammary alveolar structures: a potential regulator of involution.Cell death & disease · 2011Article
- Article
- Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.Cancer research · 2011Article
- Differentiation of the mammary epithelial cell during involution: implications for breast cancer.Journal of mammary gland biology and neoplasia · 2009Review
- Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death.Cancer biology & therapy · 2008Article
- Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer.Breast cancer research : BCR · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammary gland involution, characterized by extensive apoptosis and structural remodelling of the gland, is the process by which the gland is returned to the pre-pregnant state. A key advantage of the mammary gland is the ability to synchronize involution through forced weaning, thus allowing the dissection of biochemical pathways involved in the involution process. Over the past few years, significant advances have been made in understanding the signaling pathways and downstream effectors that regulate epithelial cell apoptosis in the first phase of involution, and the importance of matrix metalloproteinases and their inhibitors in both phases of involution. The precise nature of the triggers for apoptosis, however, and the ultimate perpetrators of cell death are not yet clear. This review focuses on genes whose perturbation, either by targeted deletion or overexpression in transgenic mouse models, leads to precocious involution. The accumulating data point to a complex network of signal transduction pathways that synergize to regulate apoptosis in the involuting mammary gland.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.