ArticleThe American journal of pathology2007
Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Breast cancer heterogeneity and its implication in personalized precision therapy.Experimental hematology & oncology · 2023Review
- Article
- Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age.Stem cells and development · 2022Review
- A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer Cells.Cancer research · 2019Article
- Exosomes: recruits for tumour surveillance?Journal of thoracic disease · 2017Article
- Insights into Biochemical Alteration in Cancer-Associated Fibroblasts by using Novel Correlative Spectroscopy.ChemistryOpen · 2017Article
- Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.Nature communications · 2016Article
- Preparation and Analysis of In Vitro Three Dimensional Breast Carcinoma Surrogates.Journal of visualized experiments : JoVE · 2016Article
- Article
- Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteins.BMC cancer · 2014Article
- A FTIR imaging characterization of fibroblasts stimulated by various breast cancer cell lines.PloS one · 2014Article
- Differential gene expression of Wnt signaling pathway in benign, premalignant, and malignant human breast epithelial cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Active roles of tumor stroma in breast cancer metastasis.International journal of breast cancer · 2012Article
- Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines.Clinical & experimental metastasis · 2011Article
- The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo.BMC medicine · 2010Article
- Identification of molecular distinctions between normal breast-associated fibroblasts and breast cancer-associated fibroblasts.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2009Article
- Interlobular and intralobular mammary stroma: genotype may not reflect phenotype.BMC cell biology · 2008Article
- O-GlcNAc integrates the proteasome and transcriptome to regulate nuclear hormone receptors.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Stromal fibroblasts are important for normal breast homeostasis and regulation of epithelial growth; however, this regulatory function is altered during carcinogenesis. To study the role of fibroblasts in the development of breast cancer, fibroblasts derived from normal breast (NAFs) were incorporated into the MCF10AT xenograft model of progressive proliferative breast disease. The persistence of human NAFs in xenografts was established by intracellular labeling and tyramide-coupled fluorescent in situ hybridization. Overall, the number of MCF10AT epithelial structures was decreased, and the rate of epithelial cell apoptosis was increased in xenografts containing NAFs. However, these changes were primarily in low-grade epithelial structures, corresponding to normal or mildly hyperplastic ductal epithelium. The level and rate of apoptosis of high-grade epithelial structures, corresponding to in situ and invasive carcinoma, were not consistently altered by NAFs. In addition, there was variability in the growth-inhibitory capacity of NAFs derived from different individuals. NAFs induced changes in the morphology of high-grade MCF10AT structures and in xenograft stroma, including the composition of extracellular matrix, and increased angiogenesis and lymphocytic infiltration. These findings imply that NAFs can inhibit the growth of normal and hyperplastic epi-thelium but are less able to regulate the more transformed epithelial cells that arise during carcino-genesis.
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