ArticlePlant physiology2007
Characterization of two brassinosteroid C-6 oxidase genes in pea.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Manipulating brassinosteroid signaling pathway to genetically improve horticultural plants.aBIOTECH · 2025Review
- Brassinosteroid biosynthesis and signaling: Conserved and diversified functions of core genes across multiple plant species.Plant communications · 2024Review
- PmLBD3 links auxin and brassinosteroid signalling pathways on dwarfism in Prunus mume.BMC biology · 2024Article
- Propiconazole-induced brassinosteroid deficiency reduces female fertility by inhibiting female gametophyte development in woodland strawberry.Plant cell reports · 2023Article
- Review
- Consequences of LED Lights on Root Morphological Traits and Compounds Accumulation inInternational journal of molecular sciences · 2021Article
- Feedback Inhibition Might Dominate the Accumulation Pattern of BR in the New Shoots of Tea Plants (Frontiers in genetics · 2021Article
- Article
- Regulation of Brassinosteroid Homeostasis in Higher Plants.Frontiers in plant science · 2020Review
- Overexpression of Populus trichocarpa CYP85A3 promotes growth and biomass production in transgenic trees.Plant biotechnology journal · 2017Article
- Oxidative Cyclization in Natural Product Biosynthesis.Chemical reviews · 2017Review
- The Cytochrome P450 GeneFrontiers in plant science · 2017Article
- Ethylene Signaling Influences Light-Regulated Development in Pea.Plant physiology · 2015Article
- Evidence That Chlorinated Auxin Is Restricted to the Fabaceae But Not to the Fabeae.Plant physiology · 2015Article
- Semi-dwarfism and lodging tolerance in tef (Eragrostis tef) is linked to a mutation in the α-Tubulin 1 gene.Journal of experimental botany · 2015Article
- Strigolactones stimulate internode elongation independently of gibberellins.Plant physiology · 2013Article
- Hormonal changes during non-climacteric ripening in strawberry.Journal of experimental botany · 2012Article
- Brd1 gene in maize encodes a brassinosteroid C-6 oxidase.PloS one · 2012Article
- Reassessing the role of N-hydroxytryptamine in auxin biosynthesis.Plant physiology · 2010Article
- Auxin biosynthesis in pea: characterization of the tryptamine pathway.Plant physiology · 2009Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-6 oxidation genes play a key role in the regulation of biologically active brassinosteroid (BR) levels in the plant. They control BR activation, which involves the C-6 oxidation of 6-deoxocastasterone (6-DeoxoCS) to castasterone (CS) and in some cases the further conversion of CS to brassinolide (BL). C-6 oxidation is controlled by the CYP85A family of cytochrome P450s, and to date, two CYP85As have been isolated in tomato (Solanum lycopersicum), two in Arabidopsis (Arabidopsis thaliana), one in rice (Oryza sativa), and one in grape (Vitis vinifera). We have now isolated two CYP85As (CYP85A1 and CYP85A6) from pea (Pisum sativum). However, unlike Arabidopsis and tomato, which both contain one BR C-6 oxidase that converts 6-DeoxoCS to CS and one BR C-6 Baeyer-Villiger oxidase that converts 6-DeoxoCS right through to BL, the two BR C-6 oxidases in pea both act principally to convert 6-DeoxoCS to CS. The isolation of these two BR C-6 oxidation genes in pea highlights the species-specific differences associated with C-6 oxidation. In addition, we have isolated a novel BR-deficient mutant, lke, which blocks the function of one of these two BR C-6 oxidases (CYP85A6). The lke mutant exhibits a phenotype intermediate between wild-type plants and previously characterized pea BR mutants (lk, lka, and lkb) and contains reduced levels of CS and increased levels of 6-DeoxoCS. To date, lke is the only mutant identified in pea that blocks the latter steps of BR biosynthesis and it will therefore provide an excellent tool to further examine the regulation of BR biosynthesis and the relative biological activities of CS and BL in pea.
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