ArticleGenome research2007
Using genomic data to unravel the root of the placental mammal phylogeny.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 1 of them a synthesis that pooled it.
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Who cites it
201 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evolutionary Models for the Diversification of Placental Mammals Across the KPg Boundary.Frontiers in genetics · 2019Pooled it
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- Accurate, scalable, and fully automated inference of species trees from raw genome assemblies using ROADIES.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Completing a molecular timetree of Afrotheria.Frontiers in bioinformatics · 2025Article
- Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A.Cellular and molecular life sciences : CMLS · 2024Article
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- Functional or Vestigial? The Genomics of the Pineal Gland in Xenarthra.Journal of molecular evolution · 2021Article
- The role of neutral and adaptive genomic variation in population diversification and speciation in two ground squirrel species of conservation concern.Molecular ecology · 2021Article
- Odorant-binding proteins in canine anal sac glands indicate an evolutionarily conserved role in mammalian chemical communication.BMC ecology and evolution · 2021Article
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- Exploring the ontogenetic development of the inner ear in Aardvarks.Journal of anatomy · 2021Article
- Hovlinc is a recently evolved class of ribozyme found in human lncRNA.Nature chemical biology · 2021Article
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- Vasomotor effects of 5-hydroxytryptamine, histamine, angiotensin II, acetylcholine, noradrenaline, and bradykinin on the cerebral artery of bottlenose dolphin (Tursiops truncatus).The Journal of veterinary medical science · 2020Article
- Insertion of Telomeric Repeats in the Human and Horse Genomes: An Evolutionary Perspective.International journal of molecular sciences · 2020Article
141 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
The phylogeny of placental mammals is a critical framework for choosing future genome sequencing targets and for resolving the ancestral mammalian genome at the nucleotide level. Despite considerable recent progress defining superordinal relationships, several branches remain poorly resolved, including the root of the placental tree. Here we analyzed the genome sequence assemblies of human, armadillo, elephant, and opossum to identify informative coding indels that would serve as rare genomic changes to infer early events in placental mammal phylogeny. We also expanded our species sampling by including sequence data from >30 ongoing genome projects, followed by PCR and sequencing validation of each indel in additional taxa. Our data provide support for a sister-group relationship between Afrotheria and Xenarthra (the Atlantogenata hypothesis), which is in turn the sister-taxon to Boreoeutheria. We failed to recover any indels in support of a basal position for Xenarthra (Epitheria), which is suggested by morphology and a recent retroposon analysis, or a hypothesis with Afrotheria basal (Exafricoplacentalia), which is favored by phylogenetic analysis of large nuclear gene data sets. In addition, we identified two retroposon insertions that also support Atlantogenata and none for the alternative hypotheses. A revised molecular timescale based on these phylogenetic inferences suggests Afrotheria and Xenarthra diverged from other placental mammals approximately 103 (95-114) million years ago. We discuss the impacts of this topology on earlier phylogenetic reconstructions and repeat-based inferences of phylogeny.
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