ReviewMitochondrion
Regulation of mitochondrial DNA content and cancer.
Review in Mitochondrion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Effects of high adherence to mediterranean or low-fat diets in medicated secondary prevention patients.The American journal of cardiology · 2011Trial
- Mitochondria-Associated Pathways in Cancer and Precancerous Conditions: Mechanistic Insights.International journal of molecular sciences · 2025Review
- Mitochondrial Dysfunction in Aging and Cancer.Journal of clinical medicine · 2019Review
- Mitochondrial localization, import, and mitochondrial function of the androgen receptor.The Journal of biological chemistry · 2019Article
- The Mitochondrial Endonuclease M20 Participates in the Down-Regulation of Mitochondrial DNA in Pollen Cells.Plant physiology · 2018Article
- Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells.Scientific reports · 2017Article
- Use of the Prostate Core Mitomic Test in Repeated Biopsy Decision-Making: Real-World Assessment of Clinical Utility in a Multicenter Patient Population.American health & drug benefits · 2016Article
- D-loop somatic mutations and ∼5 kb "common" deletion in mitochondrial DNA: important molecular markers to distinguish oral precancer and cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Association of leukocyte mitochondrial DNA copy number with colorectal cancer risk: Results from the Shanghai Women's Health Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Simultaneous quantification of mitochondrial DNA copy number and deletion ratio: a multiplex real-time PCR assay.Scientific reports · 2014Article
- Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2.Oncogenesis · 2013Article
- Mitochondrial DNA mutations and breast tumorigenesis.Biochimica et biophysica acta · 2013Review
- Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity).Cancers · 2011Article
- Genetic insights into OXPHOS defect and its role in cancer.Biochimica et biophysica acta · 2011Review
- Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre survey.Mitochondrion · 2011Article
- Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin.PloS one · 2011Article
- Tissue and data archives from irradiation experiments conducted at Argonne National Laboratory over a period of four decades.Radiation and environmental biophysics · 2010Review
- Article
- Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer.BMC cancer · 2009Article
- Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors.Molecular cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Enzymatic activities of the proteins encoded in nuclear genome are regulated by transcriptional, translational and post-transcriptional level. Enzymatic activities of proteins encoded in mitochondrial DNA (mtDNA) have been considered to be regulated by the same steps although detailed mechanisms might differ. However, dynamic change of the number of mtDNA, from some hundred to more than ten thousand, should be considered as another novel mechanism to regulate mtDNA-encoded proteins. Recently, we showed the connection of mtDNA depletion and deletion to cancer progression [Higuchi, M., Kudo, T., Suzuki, S., Evans, T.T., Sasaki, R., Wada, Y., Shirakawa, T., Sawyer, J.R., Gotoh, A., 2006. Mitochondrial DNA determines androgen dependence in prostate cancer cell lines. Oncogene 25, 1437-1445]. This review focuses and describes the possible connections of the mitochondrial DNA depletion and deletion to cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.