ArticleJournal of neuroimmunology2007
Autonomic neurotransmitters modulate immunoglobulin A secretion in porcine colonic mucosa.
Article in Journal of neuroimmunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- The Mechanisms of Polysaccharides from Tonic Chinese Herbal Medicine on the Enhancement Immune Function: A Review.Molecules (Basel, Switzerland) · 2023Review
- The enteric nervous system.Physiological reviews · 2023Review
- Outcomes of nicotinic modulation on markers of intestinal IgA antibody response.Biomedical reports · 2023Article
- Role of brain-gut-muscle axis in human health and energy homeostasis.Frontiers in nutrition · 2022Review
- Norepinephrine affects the interaction of adherent-invasiveVirulence · 2021Article
- Effects of Glucose Oxidase Supplementation on the Growth Performance, Antioxidative and Inflammatory Status, Gut Function, and Microbiota Composition of Broilers Fed Moldy Corn.Frontiers in physiology · 2021Article
- Purification, characterization and in vitro and in vivo immune enhancement of polysaccharides from mulberry leaves.PloS one · 2019Article
- Cholinergic Activation Enhances Resistance to OralFrontiers in immunology · 2018Article
- Large Animal Models: The Key to Translational Discovery in Digestive Disease Research.Cellular and molecular gastroenterology and hepatology · 2016Article
- Porcine models of digestive disease: the future of large animal translational research.Translational research : the journal of laboratory and clinical medicine · 2015Review
- Advances in swine immunology help move vaccine technology forward.Veterinary immunology and immunopathology · 2014Review
- Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract.Autonomic neuroscience : basic & clinical · 2014Review
- Stress modulates intestinal secretory immunoglobulin A.Frontiers in integrative neuroscience · 2013Review
- Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.The Journal of comparative neurology · 2013Article
- Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells.Journal of neuroimmunology · 2013Article
- Caloric restriction modifies both innate and adaptive immunity in the mouse small intestine.Journal of physiology and biochemistry · 2012Article
- Food fight! Parenteral nutrition, enteral stimulation and gut-derived mucosal immunity.Langenbeck's archives of surgery · 2009Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Secretory immunoglobulin A (sIgA) plays a crucial role in mucosal surface defense. We tested the hypothesis that colonic sIgA secretion is under enteric neural control. Immunohistochemistry of the porcine distal colonic mucosa revealed presumptive cholinergic and adrenergic nerve fibers apposed to secretory component (SC)-positive crypt epithelial cells and neighboring IgA(+) plasmacytes. The cholinomimetic drug carbamylcholine elicited rapid, atropine-sensitive IgA secretion into the luminal fluid bathing mucosal explants mounted in Ussing chambers. The adrenergic receptor agonist norepinephrine also increased IgA secretion, an action inhibited by phentolamine. These effects were independent of agonist-induced anion secretion. In Western blots of luminal fluid, both agonists increased the density of protein bands co-immunoreactive for IgA and SC. Mucosal exposure to enterohemorrhagic Escherichia coli did not affect IgA secretion, and carbamylcholine treatment did not affect mucosal adherence of this enteropathogen. Acetylcholine and norepinephrine, acting respectively through muscarinic cholinergic and alpha-adrenergic receptors in the colonic mucosa, stimulate sIgA secretion and may enhance mucosal defense in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.