ArticleExperimental neurology2007
Neurotrophin ligand-receptor systems in somatosensory cortex of adult rat are affected by repeated episodes of ethanol.
Article in Experimental neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Mystic Acetaldehyde: The Never-Ending Story on Alcoholism.Frontiers in behavioral neuroscience · 2017Review
- Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.Neurobiology of aging · 2013Article
- Neurotrophin levels at admission did not change significantly upon alcohol deprivation and were positively correlated with the BMI and LDL levels.Journal of molecular psychiatry · 2013Article
- Escalating ethanol intake is associated with altered corticostriatal BDNF expression.Journal of neurochemistry · 2009Article
- Ethanol-BDNF interactions: still more questions than answers.Pharmacology & therapeutics · 2008Review
- Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2008Review
- A high soy diet enhances neurotropin receptor and Bcl-XL gene expression in the brains of ovariectomized female rats.Brain research · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Ethanol exposure profoundly affects learning and memory and neural plasticity. Key players underlying these functions are neurotrophins. The present study explored the effects of ethanol on the distribution of neurotrophins in the cerebral cortex of the adult rat. Age- and weight-matched pairs of adult male, Long-Evans rats were fed a liquid, ethanol-containing (6.7% v/v) diet or pair-fed an isocaloric control diet three consecutive days per week for 6, 12, 18, or 24 weeks. Brains were processed immunohistochemically for nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression and for the expression of three neurotrophin receptors, p75, trkA, and trkB. Total numbers of immunolabeled neurons in specific layers of somatosensory cortex of ethanol- and control-fed animals were determined stereologically. Ethanol exposure induced an increase in the numbers of NGF- or BDNF-expressing neurons and in neurotrophin content per somata. These changes were (a) time and (b) laminar dependent. In contrast, the number of receptor-expressing neurons did not change due to ethanol exposure or to length of time on the ethanol diet. Thus, ethanol induces the recruitment of cortical neurons to express neurotrophins and an increase in the amount of neurotrophin expression per neuron.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.