ArticleScoliosis2007
High pressures and asymmetrical stresses in the scoliotic disc in the absence of muscle loading.
Article in Scoliosis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 76 citations in OpenAlex.
- Preoperative mid-cervical disc degeneration is associated with residual cervical kyphosis after surgery for adolescent idiopathic scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Assessment of Vertebral Body Bone Quality in Adolescent Idiopathic Scoliosis (AIS) Using Micro-CT, qBEI, and Nanoindentation-A Case Study.JOR spine · 2026Article
- Principles Underlying Surgical Decision-Making in Lowest-Instrumented Vertebra Level Selection of Adolescent Idiopathic Scoliosis: From Traditional Landmarks to Emerging Predictive Models-A Narrative Review.Journal of clinical medicine · 2026Review
- Methodological exploration of stress-based finite element growth modeling for long-term brace treatment evaluation in adolescent idiopathic scoliosis.Medical & biological engineering & computing · 2026Article
- Advances in mechanical assessments of in vivo human lumbar spine tissues with noninvasive imaging techniques.npj biomedical innovations · 2026Review
- Multicenter validation of a surgical planning tool for lumbar vertebral body tethering simulating growth modulation over 2 years.Spine deformity · 2025Article
- Upper instrumented vertebrae selection criteria for degenerative lumbar scoliosis based on the hounsfield unit asymmetry of the first coronal reverse vertebrae: an observational study.Journal of orthopaedic surgery and research · 2023Observational
- Is coronal imbalance in degenerative lumbar scoliosis patients associated with the number of degenerated discs? A retrospective imaging cross-sectional study.BMC musculoskeletal disorders · 2023Article
- Early Revision Surgery for Distal Adding-On Correction in Lenke 1 and 2 Adolescent Idiopathic Scoliosis.Cureus · 2022Article
- Can Scoliotic Discs Be Controls for Molecular Studies in Intervertebral Disc Research? Insights From Proteomics.Global spine journal · 2022Article
- How to select the lowest instrumented vertebra in Lenke 5/6 adolescent idiopathic scoliosis patients with derotation technique.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Toward Patient Specific Models of Pediatric IVDs: A Parametric Study of IVD Mechanical Properties.Frontiers in bioengineering and biotechnology · 2021Article
- Article
- The rotation of preoperative-presumed lowest instrumented vertebra: Is it a risk factor for distal adding-on in Lenke 1A/2A curve treated with selective thoracic fusion?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020Article
- Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma.Neurospine · 2020Article
- [The effect of rib cage on the dynamic response stability of the scoliotic spine].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Article
- Natural History of Postoperative Adding-On in Adolescent Idiopathic Scoliosis: What Are the Risk Factors for Progressive Adding-On?BioMed research international · 2018Article
- The effect of sitting posture on the loads at cervico-thoracic and lumbosacral joints.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018Article
- Differences in vertebral morphology around the apical vertebrae between neuromuscular scoliosis and idiopathic scoliosis in skeletally immature patients: a three-dimensional morphometric analysis.BMC musculoskeletal disorders · 2017Article
- Tracking low back pain in adolescent idiopathic scoliosis: a prospective cohort study protocol.Chiropractic & manual therapies · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLoads acting on scoliotic spines are thought to be asymmetric and involved in progression of the scoliotic deformity; abnormal loading patterns lead to changes in bone and disc cell activity and hence to vertebral body and disc wedging. At present however there are no direct measurements of intradiscal stresses or pressures in scoliotic spines. The aim of this study was to obtain quantitative measurements of the intradiscal stress environment in scoliotic intervertebral discs and to determine if loads acting across the scoliotic spine are asymmetric. We performed in vivo measurements of stresses across the intervertebral disc in patients with scoliosis, both parallel (termed horizontal) and perpendicular (termed vertical) to the end plate, using a side mounted pressure transducer (stress profilometry)
methodsStress profilometry was used to measure horizontal and vertical stresses at 5 mm intervals across 25 intervertebral discs of 7 scoliotic patients during anterior reconstructive surgery. A state of hydrostatic pressure was defined by identical horizontal and vertical stresses for at least two consecutive readings. Results were compared with similar stress profiles measured during surgery across 10 discs of 4 spines with no lateral curvature and with data from the literature.
resultsProfiles across scoliotic discs were very different from those of normal, young, healthy discs of equivalent age previously presented in the literature. Hydrostatic pressure regions were only seen in 14/25 discs, extended only over a short distance. Non-scoliotic discs of equivalent age would be expected to show large centrally placed hydrostatic nuclear regions in all discs. Mean pressures were significantly greater (0.25 MPa) than those measured in other anaesthetised patients (<0.07 MPa). A stress peak was seen in the concave annulus in 13/25 discs. Stresses in the concave annulus were greater than in the convex annulus indicating asymmetric loading in these anaesthetised, recumbent patients.
conclusionIntradiscal pressures and stresses in scoliotic discs are abnormal, asymmetrical and high in magnitude even in the absence of significant applied muscle loading. The origin of these abnormal stresses is unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.