Evidence map›Paper›PMID 17319749›Full record

ArticlePLoS genetics2007

Elevated rates of sister chromatid exchange at chromosome ends.

M Katharine Rudd, Cynthia Friedman, Sean S Parghi, Elena V Linardopoulou, Li Hsu, Barbara J Trask

Open access · goldAbstract read
In one paragraph

Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 81 citations in OpenAlex.

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  9. Life in plastic, it's fantastic! HowFrontiers in cellular and infection microbiology · 2023
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  10. Stage-specific transposon activity in the life cycle of the fairy-ring mushroomProceedings of the National Academy of Sciences of the United States of America · 2022
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  11. Article
  12. Review
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  14. Subtelomeric Transcription and its Regulation.Journal of molecular biology · 2020
    Review
  15. Review
  16. Article
  17. Identification and characterization of a subtelomeric satellite DNA in Callitrichini monkeys.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017
    Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M Katharine RuddDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Cynthia Friedman
Sean S Parghi
Elena V Linardopoulou
Li Hsu
Barbara J Trask
Fred Hutch Cancer Center · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
Variation, functions, and dynamics of human subtelomeresR01GM057070 · NIGMS · UNIVERSITY OF WASHINGTON · PI TAPSCOTT, STEPHEN J · 1997 to 2010
$4.4M
NHGRI NIH HHS T32 HG000035NHGRI NIH HHS T32 HG00035NIGMS NIH HHS R01 GM057070NIGMS NIH HHS R01 GM57070
6 · The paper itself

Abstract

Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome.

Indexed as

Sister Chromatid ExchangeChromosomes, HumanHumansIn Situ Hybridization, FluorescenceModels, BiologicalMolecular Sequence DataTelomereTumor Cells, Cultured

Identifiers

PMID17319749
PMCPMC1802831
OpenAlexW1971118090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.